By providing a broad range of advanced imaging technologies encompassing and linking light and electron microscopy, the Facility supports many research areas, including:

• Cancer
• Cardiovascular Science
• Cell Biology
• Infection and Immunity
• Nanoscience
• Neuroscience
• Regenerative Medicine
• Synthetic Biology

Our users

Our user base currently encompasses over 350 researchers from a wide range of disciplines in the biomedical and physical sciences across the University. The impact and scope of the Wolfson Bioimaging Facility is seen in over 1000 research publications that include data acquired on our microscopes.

We advise and train researchers at all levels of their careers to optimise the use of our microscope systems and to process and analyse the data they generate.

Recent publication highlights

• Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome. Cell 186: 2219-37 (2023) 
• The PECAn image and statistical analysis pipeline identifies Minute cell competition genes and features. Nature Commun. 14: 2686 (2023)
• TFEB-dependent lysosome biogenesis is required for senescence. EMBO J. doi: 10.15252/embj.2022111241 (2023)
• Chemical communication and protocell-matrix dynamics in segregated colloidosome micro-colonies. Angew. Chem. Int. Ed. Engl. 21:e202300932 (2023)
• Podocyte protease actuated receptor 1 stimulation in mice produces focal segmental glomerulosclerosis mirroring human disease signaling events. Kidney International doi: 10.1016/j.kint.2023.02.031 (2023)
• ATG8-dependent LMX1B-autophagy crosstalk shapes human midbrain dopaminergic neuronal resilience. J. Cell. Biol. 222(5):e201910133 (2023)
• The longevity-associated BPIFB4 gene supports cardiac function and vascularization in aging cardiomyopathy. Cardiovascular Research doi: 10.1093/cvr/cvad008 (2023)
• Actin limits egg aneuploidies associated with female reproductive aging. Science Advances DOI: 10.1126/sciadv.adc9161 (2023)
• Correlative light-electron microscopy using small gold nanoparticles as single probes. Light Sci Appl. 12(1)80 (2023)
• Mineralocorticoid receptor antagonism in diabetes reduces albuminuria by preserving the glomerular endothelial glycocalyx. JCI Insight 8(5):e154164 (2023)
• Ultrasound modulates neuronal potassium currents via ionotropic glutamate receptors. Brain Stimulation 10.1016/j.brs.2023.01.1674 (2023)
• Cellular production of a de novo membrane cytochrome. Proc Natl. Acad. Sci. U.S.A. 120(16) e2300137120 (2023)
• The free fatty acid-binding pocket is a conserved hallmark in pathogenic β-coronavirus spike proteins from SARS-CoV to Omicron. Science Advances DOI: 10.1126/sciadv.adc9179 (2022)
• De novo designed peptides for cellular delivery and subcellular localisation. Nature Commun. 18: 999-1004 (2022)
• Macrophage reprogramming with anti-miR223-loaded artificial protocells enhances in vivo cancer therapeutic potential.  Advanced Science doi:10.1002/advs.202202717 (2022)
• Molecular architecture of the autoinhibited kinesin-1 lambda particle. Science Advances doi: 10.1126/sciadv.abp9660 (2022)
• Living material assembly of bacteriogenic protocells. Nature 609: 1029-37 (2022)