2020 | Bristol Medical School | University of Bristol

2020 publications

Mendelian randomization provides evidence for a causal effect of higher serum IGF-1 concentration on risk of hip and knee osteoarthritis (nih.gov)

April Hartley, Eleanor Sanderson, Lavinia Paternoster, Alexander Teumer, Robert C Kaplan, Jon H Tobias, Celia L Gregson, Rheumatology (Oxford) 1676-1686 October 2020

Collider bias undermines our understanding of COVID-19 disease risk and severity (nih.gov)

Gareth J. Griffith, Tim T. Morris, Matthew J. Tudball, Annie Herbert, Giulia Mancano, Lindsey Pike, Gemma C. Sharp, Jonathan Sterne, Tom M. Palmer, George Davey Smith, Kate Tilling, Luisa Zuccolo, Neil M. Davies, Gibran Hemani, Nature communications, 12th November 2020

Smoking, DNA Methylation, and Lung Function: a Mendelian Randomization Analysis to Investigate Causal Pathways (nih.gov)

Emily Jamieson, Roxanna Korologou-Linden, Robyn E. Wootton, Anna L. Guyatt, Thomas Battram, Kimberley Burrows, Tom R. Gaunt, Martin D. Tobin, Marcus Munafò, George Davey Smith, Kate Tilling, Caroline Relton, Tom G. Richardson, Rebecca C. Richmond, AJHG, Volume 106, Issue 3, 5th March 2020, pages 315-326

Bayesian reassessment of the epigenetic architecture of complex traits (nih.gov)

Daniel Trejo Banos, Daniel L. McCartney, Marion Patxot, Lucas Anchieri, Thomas Battram, Colette Christiansen, Ricardo Costeira, Rosie M. Walker, Stewart W. Morris, Archie Campbell, Qian Zhang, David J. Porteous, Allan F. McRae, Naomi R. Wray, Peter M. Visscher, Chris S. Haley, Kathryn L. Evans, Ian J. Deary, Andrew M. McIntosh, Gibran Hemani, Jordana T. Bell, Riccardo E. Marioni, Matthew R. Robinson, Nature Communication, 8th June 2020

Familial Confounding of the Association between Maternal Smoking in Pregnancy and Autism Spectrum Disorder in Offspring (nih.gov)

Amy E Kalkbrenner, Sandra M Meier, Paul Madley-Dowd, Christine Ladd-Acosta, Margaret Daniele Fallin, Erik Parner, Diana Schendel, Autism Research, Volume 12, Issue 1, January 2020

Simulations and directed acyclic graphs explained why assortative mating biases the prenatal negative control design (nih.gov)

Paul Madley-Dowd, Dheeraj Rai, Stanley Zammit, Jon Heron, Journal of Clinical Epidemiology, Volume 118, February 2020, Pages 9-17.

Metabolomics analysis in adults with high bone mass identifies a relationship between bone resorption and circulating citrate which replicates in the general population (nih.gov)

April Hartley, Lavinia Paternoster, David M. Evans, William D. Fraser, Jonathan Tang, Debbie A. Lawlor, Jon H. Tobias, Celia L. Gregson, January 2020, Clin Endocrinol (Oxf)

Mendelian randomisation with coarsened exposures (bris.ac.uk)

Matthew J. Tudball, Jack Bowden, Rachael A. Hughes, Amanda Ly, Marcus R. Munafò, Kate Tilling, Qingyuan Zhao, George Davey Smith, Volume45, Issue3, April 2021

2020 Assessing the Associations between Autism, Autistic Traits and Multiple Risk Behaviours in Adolescence: A Population-Based Birth Cohort Study (confex.com)

Amanda Ly, J Heron, D Rai, C Wright

Epigenome-wide association study of seizures in childhood and adolescence

Caramaschi, D., Hatcher, C., Mulder, R. H., Felix, J. F., Cecil, C. A. M., Relton, C. L. & Walton, E., 8 Jan 2020, Clinical Epigenetics. 12, 13.

Precision Medicine and Cardiovascular Health: Insights from Mendelian Randomization Analyses

Spiller, W., Jung, K. J., Lee, J. Y. & Jee, S. H., 1 Feb 2020,Korean Circulation Journal. 50, 2.

Cleftlip/palate and educationalattainment: cause, consequence, orcorrelation? A Mendelianrandomizationstudy

Dardani, C., Howe, L. J. M. S., Mukhopadhyay, N., Stergiakouli, E., Wren, Y. E., Humphries, K. J., Davies, A. J. V., Ho, K. M., Weinberg, S., Marazita, M., Mangold, E., Ludwig, K., Relton, C. L., Davey Smith, G., Lewis, S. J., Sandy, J. R., Davies, N. M. & Sharp, G. C., 6 May 2020, International JournalofEpidemiology.

The Effect of Attention Deficit/Hyperactivity Disorder on Physical Health Outcomes: A two-sample Mendelian randomization study

Leppert, B., Riglin, L., Wootton, R. E.,Dardani, C., Thapar, A., Staley, J. R., Tilling, K. M., Davey Smith, G., Thapar, A. & Stergiakouli, E., 16 Dec 2020, American Journal of Epidemiology. 190, 6.

ADHD and depression: investigating a causal explanation

Riglin, L., Leppert, B., Dardani, C., Thapar, A., Rice, F., O'Donovan, M. C., Davey Smith, G., Stergiakouli, E., Tilling, K. M. & Thapar, A., 6 Apr 2020, Psychological Medicine.

Health outcome prioritisation in Alzheimer’s disease: Understanding the ethical landscape

Mckeown, A. J., Turner, A. J., Angehrn, Z., Gove, D., Ly, A., Nordon, C., Nelson, M., Tochel, C., Mittelstadt, B., Keenan, A., Smith, M. & Singh, I., 21 Jul 2020, Journal of Alzheimer's Disease.

The causes and consequences of Alzheimer’s disease: phenome-wide evidence from Mendelian randomization

Korologou-Linden, R. S., Howe, L. D., Millard, L. A. C., Ben-Shlomo, Y., Williams, D. M., Davey Smith, G., Anderson, E. L., Stergiakouli, E. & Davies, N. M., 2 Sep 2020, Nature Communications.

Education, intelligence and Alzheimer’s disease: evidence from a multivariable two-sample Mendelian randomization study

Anderson, E. L., Howe, L. D., Wade, K. H., Ben-Shlomo, Y., Hill, W. D., Deary, I. J., Sanderson, E., Zheng, J., Korologou-Linden, R. S., Stergiakouli, E., Davey Smith, G., Davies, N. M. & Hemani, G., 31 Jan 2020, International Journal of Epidemiology.

Is disrupted sleep a risk factor for Alzheimer's disease? Evidence from a two-sample Mendelian randomization analysis

Anderson, E. L., Richmond, R., Jones, S. E., Hemani, G., Wade, K. H., Dashti, H. S., Lane, J. M., Wang, H., Saxena, R., Brumpton, B. M.,Korologou-Linden, R. S., Nielsen, J. B., Asvold, B. O., Abecasis, G. R., Coulthard, E. J., Kyle, S. D., Beaumont, R. N., Tyrrell, J., Frayling, T., Munafo, M. R., & 6 others, 5 Nov 2020, International Journal of Epidemiology.

Implications of selection bias for the COVID Symptom Tracker Study

Davies, N. M., Mancano, G., Herbert, A., Tudball, M. J., Morris, T. T., Griffith, G. J., Tilling, K. M., Davey Smith, G., Munafo, M. R., Walker, J. G., Hemani, G., Zuccolo, L. & Sterne, J. A. C., 2 Jun 2020, Science.

DNA methylation signature of passive smoke exposure is less pronounced than active smoking: the Understanding Society study

Hulls, P. M., de Vocht, F., Bao, Y., Relton, C. L., Martin, R. M. & Richmond, R., 1 Nov 2020, Environmental Research. 190, 10.

A systematic review protocol examining workplace interventions that aim to improve employee health and wellbeing in male-dominated industries

Hulls, P. M., Richmond, R. C., Martin, R. M. & de Vocht, F., 9 Jan 2020, Systematic Reviews. 9, 1.