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Over-the-counter nasal sprays could keep coughs, colds and flu at bay and reduce antibiotic use

Press release issued: 12 July 2024

Widely available over-the counter nasal sprays could keep upper respiratory tract infections - like colds, chest infections, flu, sore throat, and sinus infections - at bay, and prevent full-blown symptoms from developing, one of the largest trials to date to test their effectiveness finds. The research, which analysed data from nearly 14,000 adults, found overall they reduced the days of illness by around 20 per cent, and also reduced the number of days with severe symptoms, time off work or normal activities, and antibiotic use.

There is some recent evidence that using nasal sprays to wash out virus from the nose and throat, or improving immune function through increasing exercise and managing stress, could reduce the frequency and severity of respiratory infections.  To investigate this, researchers undertook a large-scale randomised trial to compare the effectiveness of two different types of nasal spray and an online resource providing advice on physical activity and stress management.

Paper: ‘A randomised multi-arm, open label trial of nasal sprays and a behavioural intervention  for respiratory infections in primary care (The Immune Defence Study)’ by Professor Paul Little et al. in The Lancet Respiratory Medicine

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