Exploring cutting-edge nanoparticle-based vaccine design using electron cryo-microscopy: the development of ADDoCoV and Gigabody19 November 2023In the realm of combating infectious diseases, a groundbreaking publication stands as a testament to the power of interdisciplinary collaboration, innovative technologies, and pioneering methodologies. This research represents a pivotal stride forward in the development of nanoparticle-based reagents targeting infectious pathogens, harnessing the integration of synthetic, computational, and high-resolution structural methods.
The synthesis of these diverse approaches culminated in the creation of two fascinating innovations: ADDoCoV, a thermostable COVID-19 nanoparticle vaccine designed for nasal administration, and a novel Gigabody, a multivalent superbinder - both tailored to combat SARS-CoV-2 and its immune-evading variants.
British Heart Foundation and Sun Life explore cardiovascular research at the University of Bristol28 September 2023We recently had the pleasure of hosting a visit from the British Heart Foundation (BHF) and their corporate partner, Sun Life, at the GW4 Facility for High-Resolution Electron Cryo-Microscopy, situated within the University of Bristol. The occasion provided an opportunity to showcase the practical aspects of cardiovascular research conducted by the Paul lab, supported by BHF funding and utilizing our facility's advanced equipment.
Cryo-EM Research reveals Zebrafish as a Promising Model for Studying Human Heart Disease23 July 2023In a recent breakthrough, researchers at the University of Bristol have utilized cryo-electron microscopy (cryo-EM) to investigate the three-dimensional structure of the cardiac thin filament in zebrafish, shedding light on its similarity to the human counterpart. The study establishes zebrafish as a valuable model for human heart diseases, particularly hypertrophic cardiomyopathy (HCM).