Time and Location: 2:00 PM, 20th March, Chemistry LT2

Speaker: Dr. Laura Russo, University of Milano Bicocca

Host: Prof Carmen Galan

Title: 'AI supported synthesis of 3D tissue models with cell fate inducing glycans'

Abstract:

The development of human tissue mimetics is crucial for the advancement of healthcare management through the generation of in vitro organs for drug screening and tissue engineering. To this purpose hydrogels mimicking the Extracellular Matrix (ECM) morphology and signaling capacity must be generated. The ECM glycosignature has a key role in the cell fate modulation, which is mediated by specific interactions with cell receptors. The generation of multifunctional glycobiomaterials employable in the design of functional organ-like constructs still represents an open challenge in the field. With the advent of Artificial Intelligence (AI) algorithms and automated manufacturing systems like 3D printing, it is now possible to control the formulation of biomaterials, limiting the combinatorial and artisanal chemical approach still utilized. Here in this talk, I will present my recent efforts to generate smart multifunctional biomaterials with patient required properties using also AI algorithms.