Regenerative medicine and stem cell therapies
Our research is focused on turning stem cell biology into stem cell medicine to treat and improve the quality of life for patients whose chronic and life-threatening diseases remain untouched by pharmaceuticals.
Our approach is strongly interdisciplinary involving stem cell biology, developmental biology, skeletal tissue biology, haematology, and epithelial cell biology. To achieve our goals we use state of the art technologies including pluripotent cell differentiation, 3D bioprinting, genetically engineered model organisms and cell lines, high throughput/high content timelapse microscopy and computational image analysis.
The knowledge gained will allow us to harness the potential of stem cells for therapies within the field of regenerative medicine. Conditions we investigate range from osteoarthritis, respiratory and heart disease, blood disorders and cancer.
Principal investigators
Understanding stem cell systems: By understanding how stem cell systems form and how they maintain our health, we aim translate basic research into new therapies. Imaging is a key technological platform for this goal. Above is an example of a large volume 3D image generated from the blood marrow (blood vessels shown in green and blood cells in white) which contains blood stem cells and mesenchymal stem cells.