Medicines and prescribing
The Medicines and Prescribing research group at the Centre for Academic Primary Care (CAPC) is a small but rapidly expanding multidisciplinary team of researchers. We have broad interests covering a range of topics related to the rational and safe use of medicines in primary care.
Areas of interest include:
- medicines optimisation
We also have active collaborations with researchers at the Universities of Cambridge, Nottingham, Oxford and Dundee, and support the provision of undergraduate teaching on pharmacology and therapeutics at Bristol Medical School.
Medicines and prescribing facts
Medications are the main therapeutic intervention offered by clinicians to improve health, with most prescribing occurring in primary care.
Over 1 billion items are dispensed annually in primary care in England alone, and prescribing accounts for the biggest proportion of non-staff expenditure by the NHS.
Over half of patients in their 70s are on at least four regular medications.
Barbara is a researcher working across a range of primary care projects, including the IMPPP trial: ‘Improving Medicines Use for People with Polypharmacy in Primary Care’ and ‘Safety and Quality of online consulting and prescribing services’. She has a PhD in social and cultural history and is currently developing work exploring historical aspects of primary care
Shoba is a Senior Research Associate with diverse experience within primary care research. She is currently leading a project investigating prescription medication sharing by primary care patients. Her research interests include medicines optimisation, patient safety, multimorbidity and systematic reviews.
Rachel is an experienced epidemiologist and supports broader work in the Department of Population Health Sciences using the CPRD database. She is involved with several pharmacoepidemiological studies, including leading a project investigating the effectiveness of cardiovascular preventative treatment in patients with multimorbidity.
Polly is a GP and NIHR In-Practice Fellow interested in multimorbidity, polypharmacy and deprescribing. She and Prof Chris Salisbury developed and validated the 'Multimorbidity Treatment Burden Questionnaire' - a widely used tool. She has applied for a NIHR doctoral fellowship focused on the characteristics and unmet care needs of housebound patients.
Mel is an Academic Administrator and provides support to Rupert Payne and the wider Medicines and Prescribing team.
Cindy is an experienced qualitative researcher specialising in process evaluation in trials of primary care interventions for people with multimorbidity. She has a particular interest in person-centred care and patient involvement in research.
Debbie is a Research Fellow with longstanding and diverse research experience and expertise within a primary health care setting. Her research interests include medicines optimisation and users' experience of medication review.
Roxanne is a Senior Research Associate focusing on the application of qualitative research methods to improve the design and conduct of health services research. She currently works on the IMPPP trial: Improving Medicines Use for People with Polypharmacy in Primary Care. She is interested in patients' experience of the health care interventions and improving the conduct of trials and interventions.
Rupert is a GP and Clinical Pharmacologist, and Consultant Senior Lecturer. He has particular interests in polypharmacy and electronic health records, and is chief investigator for the IMPPP trial. He co-authored the influential King's Fund report on polypharmacy.
Hannah is a Research Fellow and Chartered Psychologist. Her research has predominantly focussed on medicines use, medicines safety, the roles of pharmacists (particularly prescribing pharmacists) and the design and development of evidence based interventions in community pharmacy (e.g. opportunistic sexual and reproductive health advice for women prescribed opiate substitution therapy).
Charlotte is a Senior Research Associate in Primary Care Mental Health. Her research uses multi/mixed methods to understand the diagnosis and management of anxiety and depression in primary care.
Vincent is a Senior Research Associate in Research Synthesis. He has conducted systematic reviews of interventions in a range of topics including alcohol use disorder, peripheral arterial disease and surgical site infection. He is determined to improve patient and public health by identifying, appraising and synthesising available evidence. Vincent is also keen to improve the systematic review process (e.g. ROB 2 Excel tool and automated snowballing searches), trial designs and data visualisation.
Prescription medication sharing by primary care patients. Dawson S, McCahon D, Huntley A, Turner K. Funder. : Royal College of General Practitioners Scientific Foundation Board Annual Research Grant (2020-2022).
- IMPPP: Improving Medicines use in People with Polypharmacy in Primary Care. Payne RA, Salisbury C, Round J, Morris R, Jameson C, Dreischulte T, Guthrie B, Chew-Graham C. Funder: NIHR Health Services and Delivery Research (2018-2022)
- Investigating the relationship between continuity of care and patients' medication use. Tammes P, Salisbury C, Morris R, Payne R. Funder: NIHR School for Primary Care Research (June 2020-March 2021).
Maximising wellbeing in everyday life with long-term conditions (MaxWELL). Mann C, Johnson R, Salisbury C, Barnes B, Horwood J, De Vocht F, McLeod H. Funder: RCF (2020-2021)
- Diagnosis and management of infectious disease in primary care during the COVID-19 lockdown: changes in antibacterial and antiviral use. Denholm R, Payne R, Hay A. Funder: EBI (2020)
- Using linked primary care and viral surveillance data to develop risk stratification models to inform management of severe COVID19. Payne R, Kontopantelis E, Mant J, Denholm R, Cooper J, Forbes H, Herbert A, Tammes P. Funder SPCR (2020).
Medication sharing behaviours. Dawson S, Huntley A, Turner K, McCahon D. Funder: RGCP SFB (2019-2020)
- Safety and quality of online consulting and prescribing services. Payne R, McCahon D, Denholm R, Turner K, Dawson S, Watson M. Funder: RCF (2019-2020)
- What is the role of genetics in primary care? Payne R. Funder: NIHR Evidence Synthesis Working Group. Funder: NIHR School for Primary Care Research (2017-2020)
- GP perspectives on the utility of tool to effect deprescribing in clinical practice. Payne R, McCahon D, Abel G. Funder:RCF (2019)
Patient experiences and perceptions of medication review in general practice. McCahon D, Horwood J, Payne RA, Duncan P. Funder: RCGP SFB (2018-2019)
- Using national administrative data to evaluate new models of primary care prescribing. Payne RA, Denholm R, McCahon D, Kontopantelis E, Rodgers S. Funder: NIHR School of Primary Care Research (2018-2019)
- The effectiveness of CVD preventative treatment in a multi-morbid population. Denholm R, Macleod J, Payne RA, Morris R, Davies N. Funder: NIHR School for Primary Care Research (2017-2019)
Developing a model of medication review for use in clinical practice. McCahon D, Duncan P, Payne RA. Funder: RCF (2018)
- Developing a measure of inappropriate polypharmacy in primary care. Payne RA, Hay A, Morris R, MacLeod J, Avery A, Rodgers S, Burt J, Campbell S. Funder: NIHR School for Primary Care Research (2016-2018)
- Impact of hospital admission upon patterns of primary care prescribing. Payne RA, Purdy S, Morris R. Funder: NIHR School for Primary Care Research (2016-2018)