The endo-lysosomal system is composed of several membranous compartments responsible for the internalization and sorting of different cargo molecules. The system is crucial for cellular homeostasis, as it is involved in nutrient sensing and signaling, cell polarity, and cell migration.

Recent findings point towards a role for the endosomal system in metabolic homeostasis. This is supported by evidence that defects in the endocytic pathway often contribute to severe metabolic phenotypes, such as type 2 diabetes, hypercholesterolemia, and metabolic dysfunction-associated steatotic liver disease. Despite this, the molecular mechanisms that interconnect the endo-lysosomal system and metabolism remain unknown, as research has traditionally focused on studying both modules independently from each other.

The aim of the EndoConnect consortium is to change this by promoting interdisciplinary research that narrows the gap between the study of the endo-lysosomal system and metabolic research.

This EndoConnect Symposium aims to bring together leading scientists focused on molecular mechanisms, structural and cell biology, or physiological and translational research. Thus, this event will provide an up-to-date overview of the most recent discoveries concerning the role of the endosomal system in metabolism.

More information and to register