Wülfing Lab

The Wülfing laboratory is interested in understanding how T cell signalling is amplified or attenuated in health and disease. To gain unique access to the system-wide, complex processes driving such signal tuning, we directly investigate signalling and T cell function with large-scale live cell imaging approaches.

We have recently switched the focus of our laboratory from imaging signalling in mouse CD4 T cells interacting with antigen presenting cells to better understanding human cytotoxic T cells function with an emphasis of tumour-mediated immune suppression. From our CD4 T cell imaging days you can still find an overview of our determination of the spatiotemporal organisation of T cell activation with > 70 elements analysed in the section ‘Spatiotemporal patterning of T cell activation’. Our most recent publications illustrate how we generate human suppressed cytotoxic T cells and investigate the control of their function by molecular regulators and therapeutics as also summarized in the group research overview.