To reduce noise and gaseous emissions, the EU-funded ENODISE project aims at improving the integration of novel aircraft’s propulsion systems with the airframe. To achieve this, it will study the key propulsion-airframe integration issues and build a solid basis of knowledge and methods. The project will investigate integration optima using a novel experimental methodology combined with high-fidelity simulations and low-order modelling approaches. It will also implement shape modifications and innovative flow/acoustic control technologies to maximise aero-propulsive efficiency while reducing adverse installation effects. The proposed research plan should lead to better integration designs with minimal detrimental installation effects.