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New trial to assess whether rapid tests reduce antibiotic prescribing for respiratory infections in primary care

Nurse swabs throat of child

Nenad Sojkovic from Flickr under CC Attribution 2.0 Generic licence:

Press release issued: 23 November 2022

A new randomised controlled clinical trial, led by the University of Bristol, will investigate whether rapid microbiological ‘point-of-care’ tests for respiratory infections could reduce antibiotic prescribing in primary care, thanks to funding of £1.6 million by the National Institute for Health and Care Research (NIHR). The tests, which are carried out in GP surgeries rather than sent to a laboratory, detect the presence of viruses and some bacteria, with results available on the same day.

Every year, millions of people in the UK seek help for respiratory infections, such as coughs, colds, chest infections, sore throats and earaches. On average, GPs and nurses give antibiotics to half of these patients. This is more than is necessary because most respiratory infections are caused by viruses, including COVID-19, but antibiotics only work on bacteria. This is needlessly contributing to antimicrobial resistance (AMR), but since clinicians don't always know who needs them, they are often given 'just in case'.

Manufacturers are developing same-day swab tests that can detect multiple viruses associated with respiratory infections in as little as 45 minutes – fast enough for clinicians to make same-day decisions about whether to prescribe antibiotics. A UK government review published in 2016 supports their use, seeing them as critical to improving antibiotic use.

RAPID-TEST is a large randomised controlled clinical trial that will investigate whether point-of-care tests really do reduce antibiotic prescribing in general practice, and how. The project is part of a long-standing collaboration between the University of Bristol and the Bristol, North Somerset and South Gloucestershire NHS Integrated Care Board.

Professor Alastair Hay, a GP and Chief Investigator of the study based at the Centre for Academic Primary Care and the Bristol Trials Centre at University of Bristol, said: “Industry is investing a lot of money in the development of these tests and the potential future cost to the NHS is high. It’s therefore important we are confident they are a good use of scarce NHS funds before they are introduced into routine care. A well-conducted clinical trial, like RAPID-TEST, is the best way to find out.

“Although it may at first seem obvious that they should be used, there are other factors to consider in addition to cost. For example, when a virus is detected, it does not mean it is causing the infection. Some viruses can live harmlessly in our noses and throats. So, nurses and GPs must still use their judgement about whether a bacterial infection is also present.

“Second, no test is 100% accurate. It might say ‘no virus’ when an important virus is present. This means patients could be given the wrong advice or treatment. Finally, the decision to prescribe antibiotics can be influenced by factors outside the test results, such as the patient-clinician interaction and patients’ expectations for antibiotics.

“We will consider all of these factors in this trial, and will also look at whether the use of rapid point-of-care tests helps patients feel better quicker. If the tests are shown to be effective in reducing antibiotic prescribing, we will do further research on their cost-effectiveness.”

Lord Jim O’Neill, who chaired the UK government commissioned AMR review published in May 2016, said: “Many people will remember the AMR review recommended the use of rapid diagnostics to reduce unnecessary antibiotic use, so I am delighted that the NIHR has chosen to fund this important clinical trial. We know from Professor Hay’s previous research that the tests are popular with GPs and nurses. With this trial there is the opportunity to find out how effective they can be."

For more information about the trial, visit the study website.

GP practices in the South West of England who wish to take part should contact the study team at

This week is World Antimicrobial Awareness Week (18-24 November).

Further information

See also:

Editorial in British Journal of General Practice (BJGP), 2020: Point-of-care testing for respiratory infections during and after COVID-19 by Hannah Thornton, Tanzeela Khalid and Alastair D Hay.

Listen to the BJGP podcast - a more in-depth discussion about the issues raised in the BJGP editorial with Professor Alastair Hay.

About the Centre for Academic Primary Care

The Centre for Academic Primary Care (CAPC) at the University of Bristol is a leading centre for primary care research in the UK, one of nine forming the NIHR School for Primary Care Research. It sits within Bristol Medical School, an internationally recognised centre of excellence for population health research and teaching.

Follow on Twitter: @capcbristol

About Bristol Trials Centre

Bristol Trials Centre (BTC) is a UKCRC-registered Clinical Trial Unit. We offer a wide range of expertise in trials methodology, study design, study management, statistical analyses and data management, including bespoke database design. It sits within Bristol Medical School, an internationally recognised centre of excellence for population health research and teaching.

Follow on Twitter: @BrsTrialsCentre

About the NIHR

The mission of the National Institute for Health and Care Research (NIHR) is to improve the health and wealth of the nation through research. We do this by:

  • Funding high quality, timely research that benefits the NHS, public health and social care;
  • Investing in world-class expertise, facilities and a skilled delivery workforce to translate discoveries into improved treatments and services;
  • Partnering with patients, service users, carers and communities, improving the relevance, quality and impact of our research;
  • Attracting, training and supporting the best researchers to tackle complex health and social care challenges;
  • Collaborating with other public funders, charities and industry to help shape a cohesive and globally competitive research system;
  • Funding applied global health research and training to meet the needs of the poorest people in low and middle income countries.

NIHR is funded by the Department of Health and Social Care. Its work in low and middle income countries is principally funded through UK Aid from the UK government.

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