Nelson, Patlak, Worley & Standen. (1990) Calcium channels,
potassium channels and voltage dependence of arterial smooth muscle
tone. Am. J. Physiol. 259 C3:C18
This is specific to smooth muscle but many of the principals hold
for other excitable membranes, particularly cardiac. This review
article gives a clear description of how membrane voltage affects
the activity of Ca channels and, in turn, some functionally important
K channels influence membrane voltage. For those that want the
bottom line - look no further!
Cannon (1996) Ion channel defects and aberrant excitability
in myotonia and periodic paralysis. TINS 19: 3-10 (TINS =
Trends in Neurosciences)
I used this to illustrate how our new understanding of the structure
of ion channel proteins (down to their amino acid sequence) has
aided our ability to recognise the root cause of some dysfunctions.
It is likely that this knowledge will find its way into the pharmacy
in your working lifetime. This paper assumes that you appreciate
the importance of tetrodotoxin-sensitive Na channels (upstroke
of AP in nerve and muscle) but goes on to show, with the aid of
some very clear diagrams and the odd experimental record, how
identified mutations lead to dysfunctions that give rise to clinically
recognised (albeit rare) conditions.