![Dr Rajeka Lazarus](https://research-information.bris.ac.uk/ws/files/354080021/Headshot_Lazarus_2_2022.jpg)
Dr Rajeka Lazarus
MBBch, DPhil
Expertise
Current positions
Consultant Senior Lecturer in Infectious Diseases & Vaccinology
Bristol Medical School (PHS)
Contact
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Research interests
I am a clinical academic and divide my time between providing clinical care and research. I lead a programme of research which aims to prevent infectious diseases in adults through vaccination and testing. Infectious diseases are responsible for millions of deaths around the globe each year and can cause long term health problems in survivors. The treatment of infections is becoming more challenging with rise of antimicrobial resistance. Preventing infection maintains wellbeing, helps preserve antibiotics and has a lower carbon footprint than cure. My research programme is divided into the following strands.
Clinical trials of new vaccines
There are an increasing number of new vaccines in development aimed preventing infectious diseases in adults. I lead a 15-member strong vaccine delivery team based at the University Hospitals Bristol and Weston and NHS Trust and a regional vaccine delivery network. Through these teams I deliver commercial and non-commercial phase 1 to 3 vaccine trials and support the training of research staff.
Adult vaccination schedules
As the number of vaccines recommended for adults increases, evidence is needed to support how best to deliver them to maintain safety and immunogenicity. I have been awarded over £5 million in funding to investigate vaccine co-administration to inform vaccine policy. The acceptance of multiple vaccines for both those who are administering and being offered vaccines is also key to successful implementation. I aim to incorporate important implementation questions into clinical vaccine trials. I am a co-investigator on the National Immunisation Evaluation Schedules Consortium which has previously been funded by NIHR.
Opportunistic vaccination in hospital settings
One of the pillars of successful vaccine implementation is making vaccination convenient. I am working to understand how best this can be done within hospitals to reduce the number of healthcare appointments people need to attend to get vaccinated.
Improving diagnostics
Diagnosing infections leads to appropriate and timely treatment, avoid unnecessary antibiotic use and prevents onward transmission. I am working on projects to improve diagnostic pathways for tuberculosis, hepatitis C and intravascular catheter infections.
Transparency statement
I have been the Prinicpal and Chief Investigator for trials delivered through the NHS for vaccines developed by Astra-Zeneca (AZ), Valneva, Janssen, and Moderna.
I am the Chief Investigator on an investigator initiated grant from GSK
I organise meetings on behalf of the British Infection Association and UK CVN which receive sponsorship from commercial companies
I have received fees from AZ for a presentation at ECCMID 2022
Projects and supervisions
Research projects
NIHR National Immunisation Schedule Evaluation Consortium
Principal Investigator
Description
Research funding to investigate vaccine schedules for national implementationManaging organisational unit
Bristol Medical School (PHS)Dates
01/01/2024 to 01/01/2027
Combining shingles with either COVID-19 or adjuvanted influenza vaccine
Principal Investigator
Managing organisational unit
Bristol Medical School (PHS)Dates
09/01/2023
NIHR Combining Influenza and COVID-19 vaccination
Principal Investigator
Managing organisational unit
Bristol Medical School (PHS)Dates
01/04/2021 to 01/04/2023
Publications
Recent publications
30/04/2024Detection of SARS-CoV-2-specific mucosal antibodies in saliva following concomitant COVID-19 and influenza vaccination in the ComFluCOV trial
Vaccine
Working under short timescales to deliver a national trial
Trials
Prolonged T-cell activation and long COVID symptoms independently associate with severe COVID-19 at 3 months
eLife
Safety and Immunogenicity against Ancestral, Delta and Omicron Virus Variants Following a Booster Dose of an Inactivated Whole-Virus COVID-19 Vaccine (VLA2001): Interim analysis of an open-label extension of the randomized, controlled, phase 3 COV-COMPARE trial
Journal of Infection
Effect of priming interval on reactogenicity, peak immunological response, and waning after homologous and heterologous COVID-19 vaccine schedules
Lancet Respiratory Medicine