
Dr Daniel Morse
BSc, PhD
Expertise
I am a teaching and scholarship-focused lecturer in microbiology. I teach on several undergraduate units involving basic and medical microbiology, and professional programmes like medicine and dentistry.
Current positions
Lecturer in Microbiology
School of Cellular and Molecular Medicine
Contact
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Biography
My PhD at the Cardiff University School of Dentistry focused on the interactions between oral bacteria and the fungus Candida albicans in the oral cavity. I developed a biofilm model to represent the comlex multi-species biofilms commonly observed, investigated these biofilms for tissue infections after developing a 3D mucosal tissue model, and completed a clinical study to determine the bacterial microbiota associated with healthy and denture-stomatitis associated samples.
I then completed a fellowship at Cardiff University before joining the University of Bristol for a research position characterising the virulence attributes of Streptococcus pneumoniae. During the coronavirus pandemic, I was involved in a reactive project looking at bacterial secondary infections in Covid-19 positive patients.
Teaching has always been a passion of mine, and I secured a lecturer position in September 2021 and have developed as part of the Pathway 3 team to enhance teaching provision and innovation in microbiology across a number of undergradaute and postgraduate taught units.
Research interests
I have several academic/research interests arising from my background in industry R&D and academic research. I'm interested in polymicrobial biofilms and inter-kingdom interactions between oral bacteria and the fungus Candida albicans, and how virulence and pathogenicity can be modulated by oral bacteria. I'm also interested in modelling infections through use of 3D tissue models (developed and cultured in vitro) and host responses to the biofilm infections, and using probitoics to selectively modulate virulence in vitro and in vivo.
My more recent research involved characterising genes involved in Streptococcus pneumoniae virulence and pathgenicity through molecular biology techniques such as cloning, gene knockout and gene expression analyses including RNAseq, qPCR.
Publications
Recent publications
13/04/2022Targeted control of pneumolysin production by a mobile genetic element in Streptococcus pneumoniae
Microbial Genomics
Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia.
Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia.
Targeted control of toxin production by a mobile genetic element in Streptococcus pneumoniae.
Targeted control of toxin production by a mobile genetic element in Streptococcus pneumoniae.
Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring AMR bacterial pneumonia
eLife
Modulation of Candida albicans virulence in in vitro biofilms by oral bacteria
Letters in Applied Microbiology
Teaching
BDS - Lead for Y1/Y2 CMM taught components
Medical Microbiology and Infectious Diseases - Unit Director
Bench to bedside and Beyond - Unit Co-Director
Infection, Immunology and Immunity
Medical Microbiology
Infection and Immunity (MSc)
Gene expression and recombination (Co-Lead for 2022/23)
Recombinant DNA Technologies
Cellular and Molecular Pathology
Norman and Tumour Cells
Y1/Y2 Medicine (MB ChB)Case Based Learning - Lead for Body Defence