Granddaughters and great-granddaughters of men who start to smoke before puberty, have more body fat than expected, research shows
Press release issued: 21 January 2022
A new study, led by the University of Bristol and published in Scientific Reports today [21 January], has reported increased body fat in females whose grandfathers or great-grandfathers began smoking before puberty.
Experiments with model studies elsewhere have shown that exposure of males to certain chemicals before breeding can have effects on their offspring. There has, however, been doubt as to whether this phenomena is present in humans and whether any apparent effects may be more readily explained by other factors.
To investigate effects of prepubertal exposures in humans, scientists from the University of Bristol have studied possible effects of ancestral prepubertal cigarette smoking on participants in the Children of the 90s, a study of over 14,000 individuals. In earlier research from 2014, they found that if a father started smoking regularly before reaching puberty (before 11 years of age), then his sons, but not his daughters, had more body fat than expected. In the newly published study, they extended this analysis to earlier generations using recently collected data on the grandfathers and great-grandfathers of study participants obtained by questionnaires. They discovered higher body fat in females whose paternal grandfathers or great-grandfathers had started smoking before age 13 compared to those whose ancestors started smoking later in childhood (age 13 to 16). No effects were observed in male descendants. Further research will be needed to confirm these observations in other longitudinal studies and to expand the investigation into other transgenerational effects and ancestral exposures.
Professor Jean Golding, lead author of the report, said: “This research provides us with two important results. First, that before puberty, exposure of a boy to particular substances might have an effect on generations that follow him. Second, one of the reasons why children become overweight may be not so much to do with their current diet and exercise, rather than the lifestyle of their ancestors or the persistence of associated factors over the years.
“If these associations are confirmed in other datasets, this will be one of the first human studies with data suitable to start to look at these associations and to begin to unpick the origin of potentially important cross-generation relationships. It is with great thanks to participants within the Children of the 90s study that we are able to carry out such pioneering research. There is much to explore.”
'Human transgenerational observations of regular smoking before puberty on fat mass in grandchildren and great-grandchildren' by Jean Golding et al in Scientific Reports [open access]
About Children of the 90s
Based at the University of Bristol, Children of the 90s, also known as the Avon Longitudinal Study of Parents and Children (ALSPAC), is a long-term health research project that enrolled more than 14,000 pregnant women in 1991 and 1992. It has been following the health and development of the parents, their children and now their grandchildren in detail ever since. It receives core funding from the Medical Research Council, the Wellcome Trust and the University of Bristol.
About the John Templeton Foundation
The John Templeton Foundation awarded Children of the 90s approximately £1million in 2018 to collect information from the parents of the Children of the 90s about their ancestors. This was specifically to start looking at ways in which traumatic events and smoking histories might influence the development of their children.