King Edward VII granted the University its Royal Charter on 24 May 1909, enabling it to confer degrees and formally establishing the University of Bristol.
To mark the occasion, Great George - housed in the tower of the Wills Memorial Building - will ring for five minutes at 12noon on Sunday.
Weighing in at 9.5 tonnes, Great George is the country's seventh largest bell. It will be rung by a team of bell ringers who swing the bell using its rope and mounted wheel to produce a louder and richer sound than when the clock hammer usually chimes.
Such ringing is saved for special occasions such as the start of the London 2012 Olympics, the Queen's Jubilee, the Royal Wedding in 2011 and, more recently, the 70th anniversary of VE Day.
Great George will be rung by the University of Bristol Society of Change Ringers, led by Matthew Tosh, one of the Society's alumni members.
Read more about the History of the University or see its interactive timeline. Tours of the Wills Memorial Building are available to book.