Professor Richard Martin gave a talk at the Cancer Research UK Prevention Strategy Meeting on 16th May 2022 at the Royal Society in London. His talk focused on utilising large-scale, population-based  genomic data to address CRUK's new cancer prevention strategy and he presented several examples of the application of genomic methods directly relevant to the strategic themes & priorities of the strategy: improving the evidence base for precision prevention; understanding molecular mechanisms; and therapeutic innovation. He then described future potential use of population-based genomic data in prevention, inspired by CRUK’s strategy, including using Mendelian randomization to identify relevant surrogate endpoints for prevention trials; Mendelian randomization of the somatic genome to identify new causes of cancer and inform risk stratification; and integration within NHS infrastructures, such as the new lung health check programme, risk stratification in rapid diagnostic centres and the NHS genomic medicine service.