Recent ICEP-led research published in Nature identifies robust causal evidence for 12 genes and glioma risk.

The researchers used a combined Mendelian randomisation and colocalisation approach to explore 27 loci associated with glioma risk to find out whether the loci are causally implicated in glioma risk, and how risk differs across tissue type and glioma subtype.

The results indicate that genetically predicted increased gene expression of 12 genes is associated with glioma. Three of the genes have not previously been identified as glioma susceptibility genes. The effect appears to be consistent across different glioma subtypes. However, risk differs across 13 brain tissues, with five candidate tissues (cerebellum, cortex, and the putamen, nucleus accumbens and caudate basal ganglia) being implicated.

These researchers contributed equally to the research: Jamie W. Robinson, Richard M. Martin, Jie Zheng and Kathreena M. Kurian. Collaborators from other institutions also contributed.

Link to paper: https://www.nature.com/articles/s41598-021-82169-5