The ALSPAC data are used to develop pipelines for identification of environmental exposures related to phenotype, and gene-environment interaction.

This is a project aimed at developing the methodologies to determine ways in which features of the environment (physical and psychosocial) may impact on the health and development through

childhood, adolescence and into adulthood. Like the GWAS approach to identifying genetic variants that are associated with outcomes, this is a hypothesis free approach which is used in

conjunction with our other projects – including on trans/inter-generational exposures. It uses Exposome techniques to identify features that may act as causative agents, confounders,

mediators or moderators; conversely it may use Phenome techniques to determine which phenotypes are associated with particular exposures.

Team members are: Genette Ellis, Steven Gregory, Yasmin Iles-Caven and Jean Golding.