Prof Saadeh Suleiman

Saadeh Suleiman (PhD, DSc) is a Professor of Cardiac Physiology. Research within his group is focused on investigating cellular mechanisms underlying the damaging effects of cardiac insults to help in the design of novel cardio-protective interventions. His work has uncovered important metabolic and ionic aspects relating to cardiac insults, the role of cardiac amino acid transporters and the mitochondria.

Current basic science research is focused on cellular/molecular/structural/functional changes associated with heart failure in different experimental disease model as well as investigating the role of mitochondria in cardioprotection afforded by cyclic-AMP/PKA/Epac signalling pathway. Clinically based research resulted in key findings including the use of warm blood cardioplegia in coronary disease but not for valve disease, ischaemic cardioplegic arrest during paediatric cardiac surgery is linked to both cardiac injury and postoperative recovery, and cardiopulmonary bypass triggers reoxygenation injury in cyanotic paediatric patients. Conceived several clinical trials, provided the scientific rationale, and participated in the design of the protocol, acted as chief scientific investigator, and supervised the associated laboratory work.

Prof Suleiman is an elected Fellow of The Physiological Society, the European Society of Cardiology, the International Academy of Cardiovascular Sciences, and the Royal Society of Biology. He is a recipient of Benjamin Meaker outgoing Professorship for Low- and Middle-Income Countries to establish links and provide advice and support.

Images of remodelled scar cardiac tissue four weeks post-infarction in pig’s left ventricle

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