Research themes
Metabolic healthHow can we use the genetic variants associated with obesity-related metabolic complications to better understand cancer risk and progression? |
Physical activity and sleepWhat hormonal and molecular factors explain how physical activity and sleep influence cancer risk and can we intervene on these risk factors to help prevent cancer and its progression? |
Smoking cessationWhat are the causal effects of nicotine (including in e-cigarettes) on cancer risk and outcomes? |
Systemic responsesHow can multi-omic systemic perturbations help us to distinguish between factors that are causal - and thus have the potential for interventions to mitigate cancer risk and progression - and associations that are non-causal but nevertheless potentially useful in cancer early detection or prediction of outcomes?
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Cancer progression and novel treatmentsWhat are the most promising molecular targets for new and repurposed chemoprevention and therapeutic drugs? |
Somatic genomicsHow do exogeneous and endogenous factors influence the cancer-causing molecular aberrations that occur in body cells? |
The programme’s substantive research questions fall into six research themes. These themes represent high translational gain and can be addressed robustly using our methods.