Major advance in race for SARS-CoV-2 inhibitor drugs20 September 2021A new advance towards the development of drugs specifically designed to inhibit a key SARS-CoV-2 enzyme is reported in the Royal Society of Chemistry's leading journal, Chemical Science. The international team, led by scientists from the Universities of Oxford and Bristol, has designed new peptide molecules and shown that they block (inhibit) the virus’s main protease [Mpro] - a prominent SARS-CoV-2 drug target.
SARS-CoV-2 transmission model suggests primary school infection could be greater this autumn than in 202013 September 2021The SARS-CoV-2 epidemic has already had a major impact on children's education, with schools having been required to implement infection control measures that have led to long periods of absence and classroom closures. With the new school year underway, risk modelling specialists at the University of Bristol have developed a new epidemiological model for SARS-CoV-2 transmission that forecasts primary school infection outbreaks could be more frequent and possibly substantially larger this autumn than in 2020, due to the more transmissive and infectious Delta variant and projected increase in community infection.
New option for how people with Covid-19 are cared for on NHS wards30 August 2021A new protocol for prone positioning — a technique commonly used to treat COVID-19 patients in respiratory distress by turning them on to their front to increase oxygen flow to the lungs, is published in the Journal of Frailty and Aging. Researchers from the University of Bristol in collaboration with clinicians at the Royal United Hospital in Bath, conducted a literature review of the manoeuvre to develop a standard protocol for the adjuvant treatment that can be used for COVID-19 patients at high risk of dying being treated in normal hospital wards.
Hundreds of millions of Africans lack basic means of preventing SARS-CoV-2 transmission, finds global study20 August 2021Millions of people across the African continent are at risk of contracting COVID-19 because of a lack of the most basic public health tools to protect themselves - including the essentials of soap and water, finds a new University of Bristol-led study published in Epidemiology & Infection. The global research collaborative finds almost 900 million Africans live without on-site water, while 700 million people lack in-home soap/washing facilities.
Long COVID in children poorly understood by doctors21 July 2021The clinical definition of long COVID in children is at present very limited and poorly understood by doctors, according to a new report published today [21 July]. The report also found that symptoms typically associated with long COVID were having a significant physical and psychological impact on children’s day-to-day lives. Long COVID is commonly used to describe signs and symptoms that continue or develop after acute COVID‑19.
New guidance published to help GPs interpret Lateral Flow Device test results2 July 2021New guidance for GPs and other health professionals on how to interpret and communicate results from Lateral Flow Device (LFDs) tests based on the current understanding of the tests’ performance is published in the BMJ. Researchers from the Universities of Bristol, Cambridge, and Trinity College Dublin have devised a calculator which aims to help doctors, who are increasingly asked by patients what they should do after receiving their results, to better advise patients on what their LFD test result means.
Public trust in science remains strong during pandemic, but study suggests some decrease in late 20201 July 2021Throughout the coronavirus pandemic, scientific research has been widely used to communicate about the disease to the public. New research to understand public views of coronavirus science has found that confidence in science among people in England from March to November 2020 was good overall although declined over this time. People who had been shielding had greater trust in November 2020 compared with their description of the views that they held in at the start of the pandemic in March 2020.
Playing wind instruments generates less aerosol than vocalisation, COVID-19 study finds29 June 2021Aerosol generated by playing woodwind and brass instruments is less than that produced when vocalising (speaking and singing) and is no different than a person breathing, new research has found. The findings, published online in the journal Aerosol Science and Technology, could be crucial to developing a roadmap for lifting COVID-19 restrictions in the performing arts, which have been significantly restricted since the start of the pandemic.
Longest known SARS-CoV-2 infection of nearly 300 days successfully treated with new therapy 24 June 2021An immunocompromised individual with the longest known PCR confirmed case of SARS-CoV-2 infection, lasting more than 290 days, has been successfully treated with two investigational monoclonal antibodies (laboratory engineered antibodies). Clinicians and researchers from the University of Bristol and North Bristol NHS Trust (NBT) worked closely to assess and treat the infection and want to highlight the urgent need for improved access to treatments for such people with persistent SARS-CoV-2 infection.
How have vaccines helped to protect the world and how can they continue to do so?16 June 2021The power of vaccines to help save lives and shape our world has never been more evident as countries around the world fight against COVID-19. The pandemic has also highlighted how vital it is for industry, academia and global populations to work together in the race for effective vaccines. The importance of vaccine research to global public health will be discussed later this week by a distinguished panel of experts at a live online event jointly organised by the University of Bristol and Pfizer.