![Professor Seth Love](https://research-information.bris.ac.uk/ws/files/289333571/6933.jpg)
Professor Seth Love
MBBCh(Witw.), PhD(London), MRCP/FRCP, MRCPath/FRCPath
Current positions
Emeritus Professor
Bristol Medical School (THS)
Contact
Press and media
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Research interests
Seth Love is Professor of Neuropathology, and together with Professor Patrick Kehoe, leads the Dementia Research Group, a part of the Institute of Clinical Neurosciences. He is Director of the MRC UK Brain Bank Network and President of the International Society of Neuropathology. He is the lead editor of Greenfield's Neuropathology.
Professor Love's research concerns mechanisms of brain damage in dementia. His current projects are largely focused on understanding, quantifying and attempting to reverse vascular dysfunction in Alzheimer's disease and related causes of dementia, and on molecular interrelationships between Alzheimer's disease, Lewy body diseases and vascular dementia. This research is supported by the Medical Research Council, Alzheimer's Research UK, the Alzheimer's Society and BRACE (Bristol Research into Alzheimer's and Care of the Elderly).
Projects and supervisions
Research projects
(BDR MRC) Mapping cell-type-specific regulatory genomic variation in Alzheimer's disease pathology
Principal Investigator
Managing organisational unit
Bristol Medical School (THS)Dates
01/10/2021 to 30/09/2024
8068 MRC via UCL: MR/T018569/1 Defining And Diagnosing Neurodegenerative Movement Disorders Through Integrated Analysis Of Genetics And NeuroPathology (MD-GAP)
Principal Investigator
Managing organisational unit
Bristol Medical School (THS)Dates
07/01/2021 to 06/01/2024
UKDP: Integrated DEmentiA Research environment (IDEA)
Principal Investigator
Managing organisational unit
Bristol Medical School (THS)Dates
01/04/2015 to 01/04/2016
ET-1-mediated reduction of cerebral blood flow in Alzheimer's disease: therapeutic potential of zibotentan
Principal Investigator
Managing organisational unit
Bristol Medical School (THS)Dates
01/05/2013 to 28/02/2018
Epidemiological neuropathology of dementia
Principal Investigator
Managing organisational unit
Bristol Medical School (THS)Dates
01/02/2010 to 01/02/2014
Thesis supervisions
Publications
Selected publications
01/07/2013Assessing white matter ischemic damage in dementia patients by measurement of myelin proteins
Journal of Cerebral Blood Flow and Metabolism
Pathophysiology of white matter perfusion in Alzheimer's disease and vascular dementia
Brain
Post-mortem assessment of hypoperfusion of cerebral cortex in Alzheimer's disease and vascular dementia
Brain
White matter hypoperfusion and damage in dementia
Brain Pathology
Endothelin-converting enzyme-2 is increased in Alzheimer's disease and up-regulated by Abeta
American Journal of Pathology
Recent publications
12/03/2024A single nuclear transcriptomic characterisation of mechanisms responsible for impaired angiogenesis and blood-brain barrier function in Alzheimer's disease
Nature Communications
Elevated CSF angiopoietin-2 correlates with blood-brain barrier leakiness and markers of neuronal injury in early Alzheimer's disease
Translational Psychiatry
Elevated CSF angiopoietin-2 correlates with blood-brain barrier leakiness and markers of neuronal injury in early Alzheimer's disease
Translational Psychiatry
Elevated late-life blood pressure may maintain brain oxygenation and slow amyloid-β accumulation at the expense of cerebral vascular damage
Brain Communications
Is later life depression a risk factor for Alzheimer's disease or a prodromal symptom: a study using post-mortem human tissue?
Alzheimer's Research and Therapy