
Dr Scott Miners
B.Sc., Ph.D.(Wales)
Current positions
Senior Lecturer in Neuroscience
Bristol Medical School (THS)
Contact
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Research interests
I co-lead the Dementia Research Group at the University of Bristol. I am a senior lecturer and ARUK-funded Senior Research Fellow. My research focusses on understanding the causes and contribution of cerebral vascular dysfunction to dementia. I have ~20 years research experience within the field and have published over 60 original research articles and reviews. My research is internationally recognised and I have led on the development of vascular markers to assess vascular dysfunction in post-mortem brain tissue and CSF in dementia. I currently lead a research team and enjoy recruiting and mentoring the career development of junior research staff and PhD students. I have established collaborations with research groups at other UK institutions and academic colleagues overseas. I am a member the British Neuropathology Society Academic committee and the ARUK Grant review board. I regularly review grants from the MRC and national dementia charities and review original research submitted to leading neuropathology and neuroscience journals.
Projects and supervisions
Research projects
Mapping cerebrovascular (dys)function in the early stages of Alzheimer’s disease
Principal Investigator
Managing organisational unit
Bristol Medical School (THS)Dates
01/09/2024 to 31/08/2027
Investigating the relationship and modelling the impact of neuroinflammation on cerebral vascular function in dementia using novel 3D models of cerebral vasculature.
Role
Co-Investigator
Managing organisational unit
Bristol Medical SchoolDates
01/10/2022 to 02/04/2027
Thesis supervisions
Exploring the role of the renin angiotensin system in Alzheimer’s disease - investigations into genetic variations and neuropathology
Supervisors
Investigations of the classical and non-classical axis of the renin angiotensin system in dementia
Supervisors
Endothelin-1 mediated vasoconstriction and cerebral hypoperfusion in Alzheimer’s disease
Supervisors
Age-associated changes in the renin-angiotensin system
Supervisors
Neuromodulation and neurotrophic factors
Supervisors
Publications
Recent publications
01/12/2024Association between plasma angiotensin converting enzyme 1 level and cognition over 12-years
Altered Gene Expression Within the Renin–Angiotensin System in Normal Aging and Dementia
Journals of Gerontology, Series A
A single nuclear transcriptomic characterisation of mechanisms responsible for impaired angiogenesis and blood-brain barrier function in Alzheimer's disease
Nature Communications
Dysregulation of the renin-angiotensin system in vascular dementia
Brain Pathology
Elevated CSF angiopoietin-2 correlates with blood-brain barrier leakiness and markers of neuronal injury in early Alzheimer's disease
Translational Psychiatry