Dr Patrick Case
Current positions
Contact
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Research interests
I am currently doing a PhD in Music and am studying how computer software may help a composer to be creative.
My previous research interests were in the synaptic plasticity in sympathetic ganglia and the retina, the body's response to orthopaedic metals from joint replacements and the mechanisms for the fetal origins of adult disease.
Projects and supervisions
Research projects
How to deliver growth signals to the placenta using nanoparticles
Managing organisational unit
Bristol Medical School (THS)Dates
01/11/2013 to 01/11/2016
BIOLOGICAL CONSEQUENCES OF EXPOSURE TO PROSTHETIC METALLIC NANOPARTICLES
Managing organisational unit
Bristol Medical School (THS)Dates
01/04/2009 to 01/04/2012
The in vitro genotoxicity of orthopaedic ceramic (Al2O3) and metal (CoCr alloy) particles
Description
Alumina Oxide particulates are generally less genotoxic than Cobalt Chrome alloy particulates when tested in vitro. However, the smaller size of Alumina wear particles from THAs may cause mechanical disruptions…Managing organisational unit
Bristol Medical School (THS)Dates
05/11/2003 to 20/12/2007
SURFACT ANALYSIS OF ORTHOPAEDIC IMPLANTS - LINKED TO RB0953
Dates
01/02/2002 to 01/02/2005
Publications
Recent publications
01/07/2023Placenta-targeted treatment with nMitoQ prevents an endothelin receptor A pathway cardiac phenotype observed in adult male offspring exposed to hypoxia in utero
AJP - Heart and Circulatory Physiology
Cortical cells are altered by factors including bone morphogenetic protein released from a placental barrier model under altered oxygenation
Neuronal Signaling
DNA damage signalling from the placenta to foetal blood as a potential mechanism for childhood leukaemia initiation
Scientific Reports
In vitro placenta barrier model using primary human trophoblasts, underlying connective tissue and vascular endothelium
Biomaterials
Sex-Specific Effects of Nanoparticle-Encapsulated MitoQ (nMitoQ) Delivery to the Placenta in a Rat Model of Fetal Hypoxia
Frontiers in Physiology
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