![Professor Moin Saleem](https://research-information.bris.ac.uk/ws/files/289537575/IMG_5241_.jpg)
Professor Moin Saleem
M.B.,B.S., Ph.D.(Lond.), F.R.C.P.
Expertise
Professor and Consultant Paediatric Nephrologist, Bristol Children's Hospital; Director of Bristol Renal; Glomerular disease research including podocyte biology and nephrotic syndromes; Founder and CSO of Purespring Therapeutics
Current positions
Professor
Bristol Medical School (THS)
Contact
Press and media
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Biography
I trained as an undergraduate at University College, London. I am a Fellow of Royal College of Physicians. My PhD was in transplantation immunology at Institute of Child Health, London. Paediatric nephrology training at Great Ormond Street Hospital, London. Set up my independent laboratory programme in glomerular cell biology in Bristol, as well as holding a post as a consultant paediatric nephrologist since 1999, with an international reputation in management of nephrotic syndromes.
I now am a Director of Bristol Renal, a glomerular research group of approximately 45 researchers, covering all areas from cell biology, transgenic models and population cohorts and genetics. My specific area is in podocyte biology (H index 71).
I was the originator of the UK Renal Rare Disease Registry (RaDaR), and am currently leading the UK nephrotic syndrome study (NephroS), as well as a major industry-academic collaboration termed NURTuRE (National Unified Renal Translational Research Enterprise). I am PI on several MRC projects, including Stratified Medicine, laboratory project grants and a Global Challenges programme.
My gene therapy program commenced in 2014, and is focused on targeting the podocyte in order to radically change the treatment of kidney diseases. I am founder and chief scientific officer of Purespring Therapeutics, the world's first renal gene therapy company.
Projects and supervisions
Research projects
The role of DNA methylation in stratifying and understanding paediatric nephrotic syndrome – a combined bioinformatics and CRISPR-cas9 approach
Principal Investigator
Managing organisational unit
Bristol Medical School (THS)Dates
01/09/2021 to 31/08/2024
MRC PtoD - Prof Moin Saleem
Principal Investigator
Managing organisational unit
Bristol Medical SchoolDates
28/05/2019 to 26/07/2019
MRC PtoD - Prof Moin Saleem
Principal Investigator
Managing organisational unit
Bristol Medical SchoolDates
01/02/2019 to 31/08/2019
EBI MRC CiC - Prof M Saleem
Principal Investigator
Managing organisational unit
Bristol Medical SchoolDates
01/01/2019 to 30/06/2021
A pathway to full clinical development for the first drug to treat genetic forms of Nephrotic Syndrome
Principal Investigator
Managing organisational unit
Bristol Medical School (THS)Dates
01/08/2018 to 29/02/2020
Thesis supervisions
Investigation of novel biomarkers and treatment strategies in steroid-resistant nephrotic syndrome
Supervisors
Investigating Adeno-Associated Virus as a Vector for Gene Therapy for Steroid-Resistant Nephrotic Syndrome
Supervisors
Effects of disease-causing mutations of podocin on podocyte biology
Supervisors
The Role of the Podocyte in Shiga Toxin Associated Haemolytic Uraemic Syndrome
Supervisors
Understanding the Pathogenesis of Nephrotic Syndrome - Studying Signaling Pathways in Response to Nephrotic Plasma
Supervisors
Identifying the deleterious circulating factors in nephrotic syndrome
Supervisors
Publications
Recent publications
01/07/2024ADAM10 as a major activator of reactive oxygen species production and klotho shedding in podocytes under diabetic conditions
Biochemical Pharmacology
A targeted gene panel illuminates pathogenesis in young people with unexplained kidney failure
Journal of Nephrology
Bridging the 13-Year Evidence Gap
Journal of the American Society of Nephrology
Correction
Clinical Proteomics
Effects of rare kidney diseases on kidney failure
Lancet (London, England)
Teaching
I have held several University teaching roles, including lead for the 4th year undergraduate paediatric course at Bristol Medical School