I trained as an undergraduate at University College, London. I am a Fellow of Royal College of Physicians. My PhD was in transplantation immunology at Institute of Child Health, London. Paediatric nephrology training at Great Ormond Street Hospital, London. Set up my independent laboratory programme in glomerular cell biology in Bristol, as well as holding a post as a consultant paediatric nephrologist since 1999, with an international reputation in management of nephrotic syndromes.

I now am a Director of Bristol Renal, a glomerular research group of approximately 45 researchers, covering all areas from cell biology, transgenic models and population cohorts and genetics. My specific area is in podocyte biology (H index 71).

I was the originator of the UK Renal Rare Disease Registry (RaDaR), and am currently leading the UK nephrotic syndrome study (NephroS), as well as a major industry-academic collaboration termed NURTuRE (National Unified Renal Translational Research Enterprise). I am PI on several MRC projects, including Stratified Medicine, laboratory project grants and a Global Challenges programme.

My gene therapy program commenced in 2014, and is focused on targeting the podocyte in order to radically change the treatment of kidney diseases. I am founder and chief scientific officer of Purespring Therapeutics, the world's first renal gene therapy company.