Professor Massimo Caputo
M.D.(Naples), M.Ch.(Bristol)
Current positions
Professor of Congenital Heart Surgery
Bristol Medical School (THS)
Contact
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Research interests
Research Interests:
Experimental
- Transcriptomics and proteonomics in congenital heart disease
- Identifying the optimal stem cell populations for vascular tissue regeneration used in congenital heart surgery
- Regenerative stem cell biology for children with heart failure
- Pulmonary hypertension
- Bicuspid aortic valve and Marfan syndrome
- Effect of oxidative stress in cardiomyocytes during different stages of postnatal development
- The role of mitochondria in increased vulnerability to cardiac insults of hearts and cardiomyocytes isolated from mice fed Western style high-fat diet
- The role of ventricular arrhythmias in sudden death associated with coronary artery disease
- Effect of oxidative stress and the role of mitochondria in hearts with chronic coronary artery disease
- The role of amino acids in cardioprotection
- Lung protection in cardiopulmonary bypass and cardioplegic arrest
Clinical
- Improving myocardial protection strategies in paediatric cardiac surgery
- RCTs on different temperature and oxygen strategies during CPB in children undergoing cardiac surgery (Thermic and Oxic Trials)
- Imaging and outcomes in adult congenital heart disease
- Atrial arrhytmias in adult and congenital cardiac diseases
- Age-related changes in excitation-contraction coupling in paediatric cardiomyocytes
- Cardioprotection with propofol during adult open heart surgery
Current group members
- Mohamed Ghorbel, Hua Lin, Sarah Martin, Jihad Hawi, Ben Littlejohns, Simon Duggan
Collaborators
- UK
Gianni Angelini, Paolo Madeddu, Andrew Halestrap, Elinor Griffiths, Raimondo Ascione, Jamie Jeremy, Barney Reeves, Andy James, Clive Orchard, Jules Hancox, Mervyn Miles, Claire Stewart. - Overseas
Andrea Venturini (Italy), Hajime Imura (Japan), Nicola King (Australia), Malcolm Underwood (Hong Kong), Chris Howarth (UAE), Camille Nassar (Lebanon).
Projects and supervisions
Research projects
Rework of Massimo Caputo BHF personal chair
Principal Investigator
Managing organisational unit
Bristol Medical School (THS)Dates
01/09/2017 to 31/08/2022
Revised submission of "The cardio-protective efficacy of cardioplegic solution supplemented with Sildenafil in neonatal pig model of cardiopulmonary bypass and cardioplegic arrest"
Principal Investigator
Managing organisational unit
Bristol Medical School (THS)Dates
18/01/2016 to 17/01/2018
Thesis supervisions
Stem cells and regenerative medicine for congenital heart disease
Supervisors
Exploration of the multi-scale nature of bicuspid aortic valve aortopathy
Supervisors
The Cardio-protective Efficacy of Cardioplegic Solution Supplemented with Sildenafil in Neonatal Pig Model of Cardiopulmonary Bypass and Cardioplegic Arrest
Supervisors
Cardiac remodelling following myocardial infarction and the cardioprotective efficacy of adrenergic stimulation against reperfusion injury in healthy and failing hearts
Supervisors
Antigenic, functional and molecular characterization of human cardiac pericytes from newborn and grown-up congenital heart disease patients
Supervisors
The interplay between hESC-derived heart progenitors and the extracellular matrix towards developing regenerative medicine treatments and investigative tools for congenital heart disease
Supervisors
Cardiac Survival Signalling, Oxidative Stress & Reperfusion Injury during Postnatal Development
Supervisors
Bio-fabricating constructs suitable for pulmonary valve replacement therapy in paediatric patients with congenital heart defect
Supervisors
Investigating the role of the extracellular matrix protein agrin in cardioprotection
Supervisors
Exploring maternal lifestyle and molecular risk factors for congenital heart disease
Supervisors
Publications
Recent publications
14/04/2025del Nido versus St. Thomas’ blood cardioplegia in the young (DESTINY) trial
BMJ Open
Impact of COVID-19 pandemic on rates of congenital heart disease procedures among children
Open Heart
Impact of COVID-19 pandemic on rates of congenital heart disease procedures among children
Open Heart
Peripandemic outcomes of infants treated for sentinel congenital heart diseases in England and Wales
Open Heart
Robust multi-label surgical tool classification in noisy endoscopic videos
Scientific Reports
Related people
Professor Gianni Angelini
BHF Professor of Cardiac Surgery and Director
Bristol Medical School (THS)
Professor Deborah Lawlor
Professor of Epidemiology, MRC Investigator and BHF Chair
Bristol Medical School (PHS)
Mr Serban Stoica
Associate Professor in Congenital Cardiac Surgery
Bristol Medical School (THS)
Dr Giovanni Biglino
Associate Professor in Bioengineering
Bristol Medical School (THS)