
Dr Jim Dunham
BA (Hons), MBChB (Hons), FRCA, PhD
Expertise
I am interested in improving pain management. I study the sensory nerves that detect damage - the nociceptors. I'm particularly interesting in their normal physiology in acute pain, and their dysfunction in chronic pain.
Current positions
Clinical Research Fellow
School of Physiology, Pharmacology & Neuroscience
Contact
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Biography
I completed my undergraduate degree in Natural Sciences at Cambridge University in 2002. Research work in academia and the pharmaceutical industry led me to my PhD with Dr. Lucy Donaldson in Bristol, which I completed in 2008. It was during my work with Lucy that I developed my interest in nociceptor physiology, using teased fibre recordings. These interests and skills were further developed during my subsequent Post Doctoral Position with Lucy and Prof. Sally Lawson.
I graduated with honours from Medical School in 2012. During my elective, I worked in Gothenburg with Prof. Olausson, Prof. Wessberg and Dr. Ackerley, where I learnt the fascinating technique of human C-fibre microneurography. The Foulkes Foundation kindly supported my research during medical school with a fellowship in 2011.
On returning to Bristol in 2015, I have progressed through the NIHR clinical academic training framework under the mentorship of Prof. Tony Pickering, firstly with an Academic Clinical Fellowship and, most recently, with a Clinical Lectureship. I have used this time to create a forward and reverse translational platform, combining my PhD preclinical models with human microneurography, to better understand nociceptor dysfunction.
These interests have opened additional research pathways. Tony and I have partnered with Ely Lilly and ALSPAC, with funding from Above and Beyond, to explore the genetics of nociceptor excitability. I also have a very exciting new partnership with Profs. Whittaker and O’Neill in Newcastle to explore technical and computing solutions to utilise microneurography in clinical diagnostics.
Research interests
I study nociceptor physiology via a forward and reverse translational platform encompasing genetics, ex-vivo, in-vivo and human (via microneurography) recordings.
Projects and supervisions
Research projects
Bridging artificial and biological touch through microstimulation
Principal Investigator
Managing organisational unit
School of Physiology, Pharmacology & NeuroscienceDates
04/11/2024 to 03/11/2026
Thesis supervisions
Pain Transduction and Transmission
Supervisors
Publications
Recent publications
16/02/2024Small fibre pathology, small fibre symptoms and pain in fibromyalgia syndrome.
Scientific Reports
odML-Tables as a Metadata Standard in Microneurography
Proceedings of the 68th Annual Meeting of the German Association of Medical Informatics, Biometry, and Epidemiology e.V. (gmds) 2023 in Heilbronn, Germany
Open-Source Real-Time Closed-Loop Electrical Threshold Tracking for Translational Pain Research
Journal of visualized experiments : JoVE
Evaluating the association of TRPA1 gene polymorphisms with pain sensitivity
BMC Medical Genomics
Multisite silicon probes enable simultaneous recording of spontaneous and evoked activity in multiple isolated C-fibres in rat saphenous nerve
Journal of Neuroscience Methods
Teaching
I teach on the 3rd year Neuroscience of Pain course led by Prof. Pickering at the University of Bristol.