Dr Dave Copland
B.Sc.(Bristol), MSc by Research, PhD
Current positions
Research Fellow
Bristol Medical School (THS)
Contact
Press and media
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Research interests
- Mechanisms of innate immune cell activation and tissue damage in ocular inflammatory and neovascular conditions.
- Control of immune responses to promote/restore tissue homeostasis and function in the eye.
- In vivo ocular imaging, using Topical Endoscopic Fundal Imaging (TEFI), Fundal Fluorescein Angiography (FA) and Optical Coherence Tomography (OCT) platforms.
- Preclinical testing of novel therapeutic approaches using ocular disease models.
Projects and supervisions
Research projects
A novel dual-target gene therapy for safe and efficacious treatment of chronic non-infectious uveitis
Principal Investigator
Managing organisational unit
Bristol Medical School (THS)Dates
01/06/2024 to 31/05/2026
Preventing AAV gene therapy associated inflammation with immunomodulatory drugs
Principal Investigator
Role
Co-Investigator
Managing organisational unit
Bristol Medical School (THS)Dates
31/01/2024 to 30/01/2025
8066 NERC: Overcoming immune resPonses to retinal gene theropy
Principal Investigator
Managing organisational unit
Bristol Medical School (THS)Dates
01/09/2021 to 31/08/2024
Overcoming immune responses to retinal gene therapy
Principal Investigator
Managing organisational unit
Bristol Medical School (THS)Dates
06/01/2021 to 05/01/2024
Thesis supervisions
Publications
Recent publications
17/01/2025Characterization of the ocular inflammatory response to AAV reveals divergence by sex and age
Molecular Therapy
Heparanase inhibition as a systemic approach to protect the endothelial glycocalyx and prevent microvascular complications in diabetes
Cardiovascular Diabetology
Replenishing IRAK-M expression in retinal pigment epithelium attenuates outer retinal degeneration
Science Translational Medicine
Replenishing Age-Related Decline of IRAK-M Expression in Retinal Pigment Epithelium Attenuates Outer Retinal Degeneration
bioRxiv
Epigenetic drug screen identified IOX1 as an inhibitor of Th17-mediated inflammation through targeting TET2
EBioMedicine
Related people
Dr Jian Liu
Senior Research Associate
Bristol Medical School (THS)
Dr Philippa Lait
Head of the MDU
Langford Clinical Veterinary Service
Professor Andrew Dick
Professor of Ophthalmology
School of Cellular and Molecular Medicine
Dr Lindsay Nicholson
Reader in Research
School of Cellular and Molecular Medicine
Dr Colin Chu
Clinical Senior Research Fellow
Bristol Medical School (THS)