
Professor Clea Warburton
B.Sc.(R'dg), Ph.D.(Lond.)
Current positions
Professor of Cognitive Neuroscience
School of Physiology, Pharmacology & Neuroscience
Contact
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Research interests
My research interests are the neural and cellular substrates of learning and memory processes in animals. I am specifically interested in the distinct contributions the perirhinal and prefrontal cortices and the hippocampal formation make to recognition memory processing.
The work conducted by my research group has involved the use of a number of complementary behavioural, pharmacological and molecular techniques to examine the neural basis of recognition memory. In earlier experiments we revealed the differential roles played by the perirhinal cortex, hippocampus and prefrontal cortex in specific components of recognition memory, namely familiairity discrimination (our ability to tell if a stimulus such as an object, is familiar or novel); object-in-place associaitive recognition memory (our ability to tell if an object has changed its location); recency recognition memory (our ability to judge how recently an object has been encountered) .
The research uses a multidisciplinary approach incorporating molecular and cellular techniques with behavioural analysis of recognition memory. Most recently my lab have used pharmacogenetics and optogenetics to manipulate specific neural pathways between defined brain regions during specific phases of memory to uncover the nature of information processing across brain wide memory circuits.
Projects and supervisions
Research projects
LEC and associative memory_April 2023
Principal Investigator
Managing organisational unit
School of Physiology, Pharmacology & NeuroscienceDates
03/04/2024 to 02/04/2027
NC3Rs CRACK-IT Testing the viability of automated SOR apparatus
Principal Investigator
Managing organisational unit
School of Physiology, Pharmacology & NeuroscienceDates
01/05/2019 to 30/06/2021
Establishing circuit, neuronal and synaptic mechanisms of associative recognition memory
Principal Investigator
Description
Wellcome Trust Joint investigator awardManaging organisational unit
School of Physiology, Pharmacology & NeuroscienceDates
01/09/2017 to 31/08/2022
Delineating the neural basis of sequence memory in the rat
Principal Investigator
Managing organisational unit
School of Physiology, Pharmacology & NeuroscienceDates
04/04/2011 to 04/04/2014
Thesis supervisions
The role of ERK and p38 MAPK signalling in visual recognition memory
Supervisors
The role of the nucleus reuniens of the thalamus in the recognition memory network
Supervisors
A Viral Approach to Translatome Profiling of CA1 Neurons During Associative Recognition Memory Formation
Supervisors
Bayesian Analysis for Neural Data
Supervisors
Defining dopaminergic projections from the midbrain to the ventral lateral and dorsal medial striatum
Supervisors
Corticothalamic interactions in associate recognition memory
Supervisors
Evaluation of the catecholaminergic system in recognition memory
Supervisors
Publications
Recent publications
03/10/2022A critical role for long-term potentiation mechanisms in the maintenance of object recognition memory in perirhinal cortex revealed by the infusion of zeta inhibitory pseudosubstrate
Frontiers in Behavioral Neuroscience
Plasticity in Prefrontal Cortex Induced by Coordinated Synaptic Transmission Arising from Reuniens/Rhomboid Nuclei and Hippocampus
Cerebral cortex communications
Why do hippocampal mossy cells matter?
Why do hippocampal mossy cells matter?
CREB transcription in the medial prefrontal cortex regulates the formation of long-term associative recognition memory
Learning and Memory
Multi-level analyses of associative recognition memory
Current Opinion in Behavioral Sciences