Professor Andrew Dick
B.Sc., M.B.B.S.(Lond.), M.D.(Aberd.), M.R.C.P.(UK), F.R.C.S.(Lond.), F.R.C.S.(Edin.), F.R.C.P.(Edin.), F.R.C.Ophth, FMedSci
Current positions
Professor of Ophthalmology
School of Cellular and Molecular MedicineProfessor of Ophthalmology
Bristol Medical School (THS)
Contact
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Research interests
Group: Inflammatory Eye Disease Group
My group's work and that of others in ophthalmology focuses on how the retina responds to injury, inflammation and degeneration. This covers areas which include:
- The control of immune responses in the retina which includes for example the interaction with microglia and inhibitory signals mediated by neuronal CD200 expression
- Autoimmune responses within the eye and brain, by studying both T cell and macrophage responses within the tissue during experimental retinal and CNS autoimmunity
- Microglial and macrophage behaviour during retinal degeneration by studying experimental models of photoreceptor degeneration
- Retinal remodelling by studying the interaction of microglia, Muller cells and retinal progenitor cells
- Role of macrophages in retinal and choroidal angiogenesis
- Development of immunomodulatory agents for the treatment of uveitis, investigated in the experimental model of uveitis
Clinically we are undertaking significant advances in human ocular immunology through both our lead of Inflammation and immunotherapeutics of Biomedical Research Centre at Moorfields Eye Hospital and UCL-Institute of Ophthalmology. This includes:
(i) proof of concept early phase trials of immunotherapeutics.
(ii) Understanding of immune responses via live in vivo imaging of leukocytes through the retinal and choroidal vasculature in man.
(iii) progressing with development of gene therapy for treatment of uveitis
Present collaborators
- Dr Lindsay Nicholson, Schoool of Cellular and Molecular Medicine
- Dr Richard Lee, School of Clinical Sciences
- Dr Denize Atan, School of Clinical Sciences
- Dr Bob Nussenblatt, National Eye Institute, USA
- Professor R Ali, Institute of Ophthalmology and Institute of Child Health, UCL
- Professor John Forrester, University of Aberdeen
- Professor Jim Bainbridge, Institute of Ophthalmology, UCL
- Professor Mike Boulton, Indiana University School of Medicine
Projects and supervisions
Research projects
Preventing AAV gene therapy associated inflammation with immunomodulatory drugs
Principal Investigator
Role
Co-Investigator
Managing organisational unit
Bristol Medical School (THS)Dates
31/01/2024 to 30/01/2025
Thesis supervisions
Publications
Recent publications
18/01/2025Age-Associated Decline in Autophagy Pathways in Retinal Pigment Epithelium and Protective Effects of Topical Trehalose in Light-induced Outer Retinal Degeneration in Mice
Characterization of the ocular inflammatory response to AAV reveals divergence by sex and age
Molecular Therapy
Imaging-based detection of anterior chamber inflammation
American Journal of Ophthalmology
Breaking Bruch's
Experimental Eye Research
Gene Therapy-Associated Uveitis (GTAU)
Progress in Retinal and Eye Research
Related people
Dr Jian Liu
Senior Research Associate
Bristol Medical School (THS)
Professor Athimalaipet Ramanan
Honorary Professor
Bristol Medical School (THS)
Dr Dave Copland
Research Fellow
Bristol Medical School (THS)
Dr Lindsay Nicholson
Reader in Research
School of Cellular and Molecular Medicine
Dr Alison Clare
Senior Research Associate
Bristol Medical School (THS)