Scientific discussion meeting organised by Professor Cliff Abraham, Professor Tim Bliss FRS, Professor Graham Collingridge CBE FRS and Professor Richard Morris CBE FRS.

The study of long-term potentiation (LTP), a form of synaptic plasticity first described in detail 50 years ago by Bliss and Lomo, has provided major insights into a huge range of brain physiological and pathophysiological processes. The meeting covers the basic molecular mechanisms of LTP, its role in learning and memory, with a particular focus on engrams, and its dysregulation in brain disorders, including Alzheimer’s disease, depression and chronic pain.

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