This 2-day course will be online and consist of live lectures followed by practical sessions using R via Posit Cloud, consequently attendees do not need to install R on their computers.

By the end of the course participants should be able to:

1. discuss the specific contributions of different omic data types for understanding and improving human health;
2. choose and apply appropriate statistical and machine learning methods for interrogating multi-omic data;
3. apply and interpret the outputs of methods for strengthening the causal inference of molecular phenotypes;
4. derive reliable single and multi-omic biomarkers for indexing exposure and predicting health outcomes; and
5. evaluate biomarker performance in terms of metrics appropriate to the context in which the biomarker will be used.

This course is intended for individuals engaged in population-based studies who wish to use omic datasets (e.g. epigenomic, transcriptomic, proteomic, metabolomic or genomic) to gain biological insights and to derive biomarkers of exposure and/or health outcomes. Attendees may have a background in epidemiology, genetics, statistics, public health or a clinical speciality. A basic knowledge of epidemiology is required and some understanding of molecular epidemiology terminology and machine learning would be advantageous. Practical knowledge of R is required as students will be processing large omic datasets in practical sessions.

Please note that this course attracts a highly multi-disciplinary audience. We do our utmost to accommodate this and ask that if in any doubt, prospective participants enquire prior to booking to check that the course is targeted at the right level for their needs.

The course will cover:

1. examples of published multi-omic analyses and models for epidemiological and medical applications;
2. statistical methods for preprocessing, discovering patterns and testing associations in omic datasets;
3. interpreting the biological relevance of omic patterns and associations;
4. estimating the heritability and proportion of variation explained by omic data;
5. methods for strengthening causal inference of molecular phenotypes;
6. approaches from machine learning for deriving reliable single and multi-omic biomarkers for indexing exposures and predicting health outcomes; and
7. application and interpretation of appropriate metrics for evaluating biomarker performance.

Dr Paul Yousefi is a data scientist who applies emerging methods in machine learning and statistical prediction to develop multi-dimensional genomic biomarkers of health risk factors, patterns of exposure, and emerging disease phenotypes.

Dr Matthew Suderman is a bioinformatician who specialises in the handling and integrated analysis of large molecular datasets for the discovery of biomarkers of disease risk and outcomes.

To make sure the course is suitable for you and you will benefit from attending, please ensure you meet the following prerequisites before booking:

Before booking this course, please make sure you read the information provided above about the target audience and prerequisites. It is important that you have access to the relevant IT resources needed for the course and meet the knowledge prerequisites to ensure you can get the most from the course.

Bookings are taken via our online booking system, for which you must register an account. To check if you are eligible for free or discounted courses please see our fees and voucher packs page. All bookings are subject to our terms & conditions, which can be read in full here.

For help and support with booking a course refer to our booking information page, FAQs or feel free to contact us directly. For available payment options please see: How to pay your short course fees.

Participants are granted access to our virtual learning platform (Blackboard) 1 to 2 weeks in advance of the course. This allows time for any pre-course work to be completed and to familiarise with the platform.

To gain the most from the course, we recommend that you attend in full and participate in all interactive components. We endeavour to record all live lecture sessions and upload these to the online learning environment within 24 hours. This allows course participants to review these sessions at leisure and revisit them multiple times. Please note that we do not record breakout sessions.

All course participants retain access to the online learning materials and recordings for 3 months after the course. 

University of Bristol staff and postgraduate students who do not wish to attend the full course may instead register for access to the 'Materials & Recordings' version of this course: Further information and bookings.

100% of attendees recommend this course*.
*Attendee feedback from 2022-2023.

Here is a sample of feedback from previous runs of this course:

"Cutting-edge methodology presented".
Course feedback, May 2022

"Very nice short course covering a lot of cool topics".
Course feedback, May 2022

"Thorough course with a variety of different aspects, and opportunity for practical work as well as taught lectures and opportunity to ask questions and have guided working".
Course feedback, May 2022

"It is an excellent course. The tutors are nice and professional and very responsive to the questions from students. The lectures cover a wide range of topics and have lots of examples from the tutors' and their colleagues' research work. In addition, R Cloud is very convenient and simple to use in the practicals".
Course feedback, May 2022