Complex biological systems involve and coordinate several mechanisms across scales. Therefore, a system-level understanding is essential in the study of the dynamics of these systems. Cells are the fundamental component of an organism, and in particular, stem cells are vital in the development and maintenance of tissues. Our group is particularly interested in the study of stem cell dynamics, their capacity of self-renewal, differentiation and their role in the early stages of a system's self-organisation. The MBC group is involved in the development of models that allow us to analyse intracellular protein interactions, signalling pathways, genetic networks and biomechanical interactions to predict and understand system behaviours.

 Latest projects:

•  Development of a mathematical model that describes a gene regulatory network in mouse embryonic stem cells.
•  Design of multi-scale agent-based models involving signalling, cell-cycle and biomechanical interactions to predict intestinal cell dynamics.
•  Generation of a phase oscillator model to shed light on the physiology behind gene expression and cellular activity in the dorsal vagal complex (DVC).