Aerosol Generating Procedures and Disease Transmission

Aerosol generation occurs when tiny droplets of liquid are suspended in the air. Aerosols can be generated during many medical procedures. Some medical procedures might produce more aerosols than others, and particles of different sizes, although there remains considerable uncertainty about the risks of aerosol generating procedures (AGPs) leading to airborne disease transmisison. What is known is that aerosols can carry viruses, like coronavirus, which risks further infections if inhaled by healthcare staff or other patients. Due to this potential risk, many operations have been delayed or are being performed with extra personal protective equipment, greatly reducing the ability of the NHS and healthcare services to resume important services.

The AERATOR study (AERosolisation And Transmission Of SARS-CoV-2 in Healthcare Settings) aims to rapidly study the amount and type of aerosol generated when medical procedures are performed, and how infectious this aerosol is. The AERATOR study will address a critical gap in evidence by quantifying the concentration, size and temporal and spatial dynamics of aerosols produced during routine medical & surgical procedures in different environments. This will focus on five clinical specialties particularly impacted by procedural aerosolisation: dental, orthopaedic, respiratory, critical care and ophthalmology. These measurements will be performed using specialist equipment in operating theatres and wards to measure real-life aerosol generation. By using specialist equipment, only available at Bristol University, we can also investigate how long coronavirus survives in clinical environments.

The aim of AERATOR and accompanying studies is to provide vital information that can inform how best to organise operating theatres, medical procedures, out-patient clinics, wards and use of protective equipment, in order to protect patients and staff while maximising the ability of the NHS to resume life-saving work.

Aerosol generation can occur in many medical procedures. In AERATOR, we have studied a wide range of potential AGPs quantifying and comparing aerosol yield to typical respirable emissions from breathing and coughs.
Respiratory therapies such as Continuous Positive Airway Pressure (CPAP) have been studied for the potential as AGPs.

Relevant Publications

[1] Brown, J.; Gregson, F. K. A.; Shrimpton, A.; Cook, T. M.; Bzdek, B. R.; Reid, J. P.; Pickering, A. E. A Quantitative Evaluation of Aerosol Generation during Tracheal Intubation and Extubation. Anaesthesia 2021, 76, 174–181. pdf

[2] Gregson, F. K. A.; Shrimpton, A. J.; Hamilton, F.; Cook, T. M.; Reid, J. P.; Pickering, A. E.; Pournaras, D. J.; Bzdek, B. R.; Brown, J. Identification of the Source Events for Aerosol Generation during Oesophago-Gastro-Duodenoscopy. Gut 2021, 1–8. pdf

[3] Hamilton, F.; Arnold, D.; Bzdek, B. R.; Dodd, J.; Reid, J.; Maskell, N. Aerosol Generating Procedures: Are They of Relevance for Transmission of SARS-CoV-2? Lancet Respir. Med. 2021, 9 (7), 687–689. pdf

[4] Hamilton, F. W.; Gregson, F. K. A.; Arnold, D. T.; Sheikh, S.; Ward, K.; Brown, J.; Moran, E.; White, C.; Morley, A. J.; Bzdek, B. R.; Reid, J. P.; Maskell, N. A.; Dodd, J. W. Aerosol Emission from the Respiratory Tract: An Analysis of Aerosol Generation from Oxygen Delivery Systems. Thorax 2022, thoraxjnl-2021-217577. pdf

BARC Researchers

Prof. Jonathan Reid, Dr. Bryan Bzdek, Dr. Florence Gregson, Dr. Andrew Shrimpton, Dr. Sadiyah Sheikh, Dr. Victroia Hamilton, Alicja Szczepanska and Neha Yadav

BARC Collaborators

Prof. Tony Pickering,1 Dr. Jules Brown,2 Prof. Nick Maskell,2 Dr. Fergus Hamilton,2 Mr. James Murray,2 Mr. Johannes Keller,3 Dr. James Dodd,2 Dr. David Arnold,2 and Mark Gormley,4

1 Bristol Medical School, University of Bristol, 2 North Bristol NHS Trust, 3 University Hospitals Bristol and Weston NHS Foundation Trust, 4 Bristol Dental School

Funding

Elizabeth Blackwell Institute Rapid Response Call (COVID-19) 2020, Quantitation the relative risks of Bioaerosolisation from ‘Aerosol Generating Procedures’ in the Hospital Operating Theatre environment, £5k

DHSC/UKRI COVID-19 Rapid Response Grant, AERosolisation And Transmission Of SARS-CoV-2 in Healthcare Settings (AERATOR), £432,784

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