A Snapshot seminar hosted by the School of Physiology, Pharmacology and Neuroscience

Pluripotent stem cells have the unique capacity to generate all the cell types of the organism. In the embryo, they undergo concomitant changes in shape and identity to set the foundation of the body plan. What are the molecular mechanisms that coordinate shape and identity? And once a well-defined tissue architecture is acquired, how does it modulate pluripotent stem cell identity, differentiation and fate? To address these questions our group focuses on epithelial tissue determinants and their contribution to stem cell fate. Our final aim is to understand the molecular basis of human embryogenesis, and how the exquisite coordination between fate and shape is affected when development fails.

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