A. The Structure of proteins
1. Enzymes are Machines made of Protein
2. Amino Acid Structure and Function
3. Primary and Secondary Structures of Proteins
7. Cofactors.
B. Experimental Details of Studying Enzyme Reactions
C. 10. Inhibition of Enzyme Reactions
10a Reversible Competetive Inhibition
10b Reversible Uncompetetive Inhibition
10c Reversible Non-Competetive Inhibition
10d Reversible Mixed Inhibition
D. 11 Forces Responsible for Enzyme/Substrate and Enzyme/Inhibitor Binding
E. 12 Examples of Substrate/Inhibitor/Cofactor Binding Modes
12a Pyruvate Bound in the active site of Lactate Dehydrogenase - Hydrogen Bonds, Electrostatic Interactions, Hydrophobic Interactions.
12b 4-Iodopyrazole, Zn and NADH bound in the active site of Human Alcohol Dehydrogenase - Zn Binding, Catoion Pi interaction
12c Reversible Inhibition - Cimetidine as an inhibitor of Alcohol Dehydrogenase
12d Thymidylate Synthase Binding an Anti-Cancer Drug- Pi Stacking Interactions.
F. Design of anti-HIV compounds (HIV Protease Inhibitors)
13a HIV Protease as a drug target - substrate binding and mechanism
13b Active Site of HIV Protease
13c Peptide Based Reversible Inhibitors
13d HIV Protease binding Ro 31-8959
G. Design of anti-Cancer Compounds (Inhibitors of nucleotide biosynthesis)
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