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News from James Hodge

Press release issued: 30 November 2022

Grants

1.

2023-(28), Jazz Pharmaceuticals / GW Pharma Industrial Funding, “The UK Natural history of epilepsy and standards of care in Tuberous Sclerosis Complex”, £304,751, Dr James Hodge and Dr Sam Amin

2.

2023-(26), MRC Network Grant, “Mental Health and Circadian Science Network”, £780,757, co-PI, 0.72% Dr James Hodge, Prof Matt Jones and PI Prof Daniel Smith (University of Edinburgh).

3.

2023-(24), Genetics Society Special Interest Group Funding, “South West Fly Meeting”, £1100, PI, 1%.

4.

2022-(23), ARUK, “Enhancing sleep to delay the progression of tauopathy”, £49,995, co-PI, Dr James Hodge, Prof Matt Jones and PI Dr Michelle Bellesi

 

Papers

1. Dr James Hodge lab in collaboration with Pharmasum Therapeutics, Norway provide preclinical validation of a potential new Alzheimer’s disease and Down syndrome drug published in Frontiers in Pharmacology:

“DYRK1A inhibitor mediated rescue of Drosophila models of Alzheimer's disease-Down Syndrome phenotypes” Bangfu Zhu, Tom Parsons, Wenche Stensen, John S Mjøen Svendsen, Anders Fugelli & James J L Hodge, Frontiers in Pharmacology http://journal.frontiersin.org/article/10.3389/fphar.2022.881385/

2. Dr James Hodge lab working with Illuminos Therapeutics and Arizona University provide further validation of DYRK1A as a drug target for Down’s syndrome and Alzheimer’s disease published in Scientific Reports:

“DYRK1A antagonists rescue degeneration and behavioural deficits of in vivo models based on amyloid-β, Tau and DYRK1A neurotoxicity" by Bangfu Zhu, Tom Parsons, Christopher Foley, Yeng Shaw, Travis Dunckley, Christopher Hulme & James J. L. Hodge Scientific Reports, https://rdcu.be/cWanY

3. Dr James Hodge’s Lab working with Dr Anir Majumdar’s team at the Children’s Hospital, Bristol has published work characterising a new rare genetic disease and neuropathy in Clinical Genetics:

 

“Hereditary spastic paraparesis presenting as cerebral palsy due to ADD3 variant with mechanistic insight provided by a Drosophila γ-adducin model” Sanchez Marco SB, Buhl E, Firth R, Zhu B, Gainsborough M, Beleza-Meireles A, Moore S, Caswell R, Stals K, Ellard S, Kennedy C, Hodge JJL, Majumdar A. http://doi.org/10.1111/cge.14220

 

4. In collaboration with Dr Michele Bellesi (Italy)

El Alaoui AA, Buhl E, Galizia S, James JL Hodge, de Vivo L, Bellesi M (2022) Increased interaction between endoplasmic reticulum and mitochondria following sleep deprivation. BMS Biology

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