Directory of Experts
Details for Professor Craig McArdle
| Personal details | |
| Name | Professor Craig McArdle |
| Job title | Professor of Molecular Pharmacology |
| Department | Bristol Medical School (THS) University of Bristol |
| Personal web page | http://www.bristol.ac.uk/clinical-sciences/people/craig-a-mcardle/overview.html |
| Contact details | This expert can be contacted via the University of Bristol Public Relations
Office. To help us deal with your request, please mention the Directory of Experts when contacting the Public Relations Office. work+44 (0)117 331 8092 email: public-relations@bristol.ac.uk |
| Qualifications | B.Sc., Ph.D.(C.N.A.A.) |
| Professional details | |
| Membership of professional bodies | Bristish Pharmacological Society, Society for Endocrinology, Endocrine Society |
| Keywords | cell signalling G-protein coupled receptor signalling G-protein coupled receptor trafficking gonadotrophin-releasing hormone signalling ERK signalling |
| Areas of expertise | My research interests are in cell signalling and reproductive endocrinology and most of my group's work focuses on the hypothalamic decapeptide GnRH, that acts via G-protein coupled receptors on pituitary gonadotrophs to mediate control of reproduction by the CNS. Type I mammalian GnRH receptors are unique in that they lack the C-terminal tails found in other G-protein coupled receptors. Much of our recent work addresses the functional relevance of this distinction, placing emphasis on receptor desensitisation and internalisation as well as ERK activation. Most recent work exploits image-based readouts (e.g. fluorescent reporters) for activity of signalling proteins using semi-automated fluorescence microscopy (high content analysis). We are combining this with mathematical modeling to explore molecular mechanisms by which cells decode hormone pulse frequency. |
| Media experience | none |