Directory of Experts
Details for Professor Ann Williams
| Personal details | |
| Name | Professor Ann Williams |
| Job title | Professor of Experimental Oncology |
| Department | School of Cellular and Molecular Medicine University of Bristol |
| Contact details | This expert can be contacted via the University of Bristol Public Relations
Office. To help us deal with your request, please mention the Directory of Experts when contacting the Public Relations Office. work+44 (0)117 331 8092 email: public-relations@bristol.ac.uk |
| Qualifications | B.Sc., Ph.D.(Bristol) |
| Professional details | |
| Membership of professional bodies | BACR EACR |
| Keywords | key events in early colorectal carcinogenesis tumour microenvironment for gene expression & function chemoprevention Regulation of apoptosis. NF-kappaB/Bcl-3 regulation in colorectal carcinogenesis, Bag-1 |
| Areas of expertise | -Dynamism in transcription factor function in response to microenvironmental stress provides new avenues for selective targeting of tumour cells and in this context. BAG-1 is a modulator of NF-kappa B signaling; this has implications for the regulation of a number of important pro-survival factors including the COX-2/prostaglandin, EGF and TGF-beta pathways. -Previously identified BAG-1 as a pRb (tumour suppressor gene) binding protein; currently studying the role of this interaction in the determination of lineage commitment in stem cells. -Recently identified the mechanism by which BAG-1 can repress gene expression via the atypical p50 NF-kappa B homodimeric pathway. -The regulation of epithelial NF-kappa B signaling in inflammatory bowel disease. The aim is identify early markers of tumorigenic progression that could be used in the management of chronic bowel disease; investigating the role of BAG-1 in the innate tumour immune response, investigating the potential for TGF-beta1 mediated regulation of anti-tumour immunity. |