Directory of Experts
Details for Dr Colin Lazarus
| Personal details | |
| Name | Dr Colin Lazarus |
| Job title | Research Collaborator |
| Department | School of Biological Sciences University of Bristol |
| Contact details | This expert can be contacted via the University of Bristol Public Relations
Office. To help us deal with your request, please mention the Directory of Experts when contacting the Public Relations Office. work+44 (0)117 331 8092 email: public-relations@bristol.ac.uk |
| Qualifications | B.Sc.(E.Anglia), Ph.D.(Bristol) |
| Professional details | |
| Keywords | plant and fungal molecular biology metabolic engineering fatty acid synthesis in fungi and plants fungal natural products secondary metabolic pathway engineering |
| Areas of expertise | My current research focuses on fungal natural products, mainly polyketides. The emphasis is on the elucidation and manipulation of secondary metabolic pathways, with the objective of generating "unnatural natural products" with enhanced or novel biological activities. This work has involved production of a "toolkit" for the heterologous expression of full biosynthetic pathways in the GRAS organism Aspergillus oryzae, and is applicable to primary and secondary metabolism from any biological source. Other metabolic engineering work has included the first production of very long chain polyunsaturated fatty acids in a higher plant, and their further conversion to prostaglandins. |