Directory of Experts
Details for Professor Adrian Mulholland
| Personal details | |
| Name | Professor Adrian Mulholland |
| Job title | Professor |
| Department | School of Chemistry University of Bristol |
| Personal web page | http://www.chm.bris.ac.uk/staff/amulholl.htm |
| Contact details | This expert can be contacted via the University of Bristol Public Relations
Office. To help us deal with your request, please mention the Directory of Experts when contacting the Public Relations Office. work+44 (0)117 331 8092 email: public-relations@bristol.ac.uk |
| Qualifications | B.Sc.(Bristol), D.Phil.(Oxon.) |
| Professional details | |
| Membership of professional bodies | Royal Society of Chemistry |
| Keywords | enzyme catalysis quantum mechanics/molecular mechanics qm/mm methods computational biochemistry enzymology modelling biological molecules drug design drug metabolism |
| Areas of expertise | Most biochemical reactions depend on enzyme catalysis, and understanding how enzymes 'work' at the molecular level is a fundamental problem. Enzymes are remarkably efficient and specific catalysts, but despite intensive experimental investigations, the detailed origins of their rate accelerations remain unclear. This question is of crucial importance in Biology, and also for the development of protein catalysts for practical applications. Better understanding is vital for analysing the activities of mutant or designed proteins, and for the design of inhibitors as pharmaceutical lead compounds in drug design. It also promises to contribute in predcitions of drug metabolism. |
| Media experience | Interviews for BCFM radio, The Economist, Seed Magazine, RSC Chemistry World; also public lectures |