Directory of Experts
Details for Professor Leo Brady
| Personal details | |
| Name | Professor Leo Brady |
| Job title | Warden Professor of Biochemistry |
| Department | Residential and Hospitality Services University of Bristol School of Biochemistry University of Bristol |
| Contact details | This expert can be contacted via the University of Bristol Public Relations
Office. To help us deal with your request, please mention the Directory of Experts when contacting the Public Relations Office. work+44 (0)117 331 8092 email: public-relations@bristol.ac.uk |
| Qualifications | B.Sc.(Macq.), D.Phil.(York) |
| Professional details | |
| Keywords | biomolecular structures protein structure molecules disease protein crystallography biomolecular interactions molecular modelling |
| Areas of expertise | My main research interest is Biomolecular Structures: The vast majority of life processes result from the binding of a protein to another molecule. Understanding these interactions at the molecular level is the key to life itself, and provides invaluable insight for the treatment of diseases. Through the study of protein structure, primarily using protein crystallography, we aim to probe crucial biomolecular interactions central to a variety of diseases. The aim is very much to use this information to accelerate the development of new drugs and therapeutics. Studies within the group focus on a variety of proteins including immune system proteins, nerve growth factor receptors, transcription factors, plant cell-signalling proteins and metabolic enzymes involved in both malaria and Alzheimer's Disease. We employ a wide range of techniques from recombinant DNA technology, protein purification and characterisation, proteomics approaches through to structure determination using crystallography and molecular modelling. |