Increased adiposity has clear observational associations with health including all-cause mortality, cardiovascular disease, type-2-diabetes and cancer. Major gaps exist in understanding the mechanisms that may underlie these relationships. We use cross-disciplinary approaches - from wet lab, dry lab, cohort studies, trials and a variety of -omics techniques - to explore these relationships and to identify potential therapeutic targets. This research aims to flag causal targets for further investigation and identify potential pathological processes.

 Our primary research questions are:

1. How does variation in adiposity influence health outcomes?
2. How do adiposity related diseases or conditions like T2D influence cancer outcomes?
3. How do measurable biological intermediaries e.g. the gut microbiome, play a role in adiposity effects in major disease areas such as metabolic disease, cancer, inflammatory conditions, immune response?

Further information

for more information about this research, please visit the the research group website.