Browse/search for people

Dr Deborah Shoemark

Dr Deborah Shoemark

Dr Deborah Shoemark
B.Sc., Ph.D.(Bristol)

Senior Research Associate (Biomolecular Modelling)

Office C62
Biomedical Sciences Building,
University Walk, Clifton BS8 1TD
(See a map)

+44 (0) 117 331 2146

Summary

Biography

Following my degree in medical biochemistry I gained a PhD in enzymology, both at Bristol University, with Professors John Holbrook and Anthony Clarke. I spent my first post-doc combining enzymology with structural biology and mutagenesis to further explore enzyme structure and function. I then moved into drug discovery programmes as a molecular modeller involving Trks A and B and the neurotrophins. This work was targeting pain management (in the periphery) and Alzheimer's disease (centrally). Following that I worked with the MRC Prion Unit and identified compounds capable of stabilizing the human prion protein with low micromolar affinity towards a treatment for Creutzfeld Jacob's disease. This was achieved using the Bristol University Docking Environment (BUDE) software written by Dr Richard Sessions, for which I had beta tested the release version and compiled tutorials and user manual.  I then "side-lined" for a while setting up the beginnings of what I hope will lead to clinical trial to see whether targeting oral bacteria in the mouths of patients with mild Alzheimer's helps to slow disease progression. This was set up as a result of the compelling circumstantial evidence linking oral health to Alzheimer's. I myself and others had also found direct evidence of oral bacteria in samples taken post mortem from the brains of elderly donors.  

I have now moved back into the arena of molcular modelling. In particular I am using atomistic molecular modelling methods to explore the sequence/structure relationships in nanoparticles including self-assembling peptide cages (SAGES). 

Memberships

Organisations

School of Biochemistry

Other sites

Recent publications

View complete publications list in the University of Bristol publications system

Edit this profile If you are Dr Deborah Shoemark, you can edit this page. Login required.

PDF versionDownload PDF